Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313382022> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4313382022 endingPage "219.1" @default.
- W4313382022 startingPage "219.1" @default.
- W4313382022 abstract "Abstract Multiple Sclerosis is a chronic, autoimmune disease for which there is currently no cure. Previous studies suggest transplantation of neural precursor cells (NPCs) is a promising therapeutic strategy to treat neurological disorders. Using two mouse models of MS, experimental autoimmune encephalomyelitis (EAE) and murine hepatitis virus (MHV), we have observed remyelination and decreased neuroinflammation when mice received an intra-spinal transplant of syngeneic mouse GFP-NPCs. This recovery was due to replacement of damaged cells and had little effect upon immune responses. In contrast, transplantation of xenogeneic human embryonic stem cell (hESC) derived NPCs (hNPCs) or induced pluripotent stem cell (iPSC) derived NPCs (hiNPCs) modulates the host immune response. Mice receiving intra-spinal transplants of human NPCs displayed less demyelination, decreased neuroinflammation, and an increase in T regulatory cells (Tregs). Recovery was not a result of cell replacement by hNPCs because transplanted cells underwent rapid xenograft rejection. Importantly, ablation of Tregs abrogated clinical and histopathological improvement mediated by hNPC transplantation. Furthermore, hNPCs promote the induction of naïve T cells into Tregs in co-cultures in vitro. However, the mechanisms and factors that propagate Treg induction and function resulting in subsequent endogenous remyelination remain undiscovered. We hypothesize rejection of NPCs plays a role in generation of Tregs in vitro and in vivo. Future experiments will focus on elucidating the factors from hNPCs that are responsible for Treg differentiation and evaluate the ability of syngeneic, allogeneic, and xenogeneic NPCs to generate Tregs." @default.
- W4313382022 created "2023-01-06" @default.
- W4313382022 creator A5002640166 @default.
- W4313382022 creator A5038922192 @default.
- W4313382022 creator A5064602365 @default.
- W4313382022 creator A5070391155 @default.
- W4313382022 creator A5080196678 @default.
- W4313382022 creator A5085855297 @default.
- W4313382022 date "2017-05-01" @default.
- W4313382022 modified "2023-09-27" @default.
- W4313382022 title "Evaluating the Therapeutic Potential of Transplantation of Neural Precursor Cells for Treating the Autoimmune Disease Multiple Sclerosis" @default.
- W4313382022 doi "https://doi.org/10.4049/jimmunol.198.supp.219.1" @default.
- W4313382022 hasPublicationYear "2017" @default.
- W4313382022 type Work @default.
- W4313382022 citedByCount "0" @default.
- W4313382022 crossrefType "journal-article" @default.
- W4313382022 hasAuthorship W4313382022A5002640166 @default.
- W4313382022 hasAuthorship W4313382022A5038922192 @default.
- W4313382022 hasAuthorship W4313382022A5064602365 @default.
- W4313382022 hasAuthorship W4313382022A5070391155 @default.
- W4313382022 hasAuthorship W4313382022A5080196678 @default.
- W4313382022 hasAuthorship W4313382022A5085855297 @default.
- W4313382022 hasConcept C104317684 @default.
- W4313382022 hasConcept C107459253 @default.
- W4313382022 hasConcept C124964019 @default.
- W4313382022 hasConcept C126322002 @default.
- W4313382022 hasConcept C136834591 @default.
- W4313382022 hasConcept C145103041 @default.
- W4313382022 hasConcept C169760540 @default.
- W4313382022 hasConcept C202751555 @default.
- W4313382022 hasConcept C203014093 @default.
- W4313382022 hasConcept C2776914184 @default.
- W4313382022 hasConcept C2777619251 @default.
- W4313382022 hasConcept C2778486448 @default.
- W4313382022 hasConcept C2778531937 @default.
- W4313382022 hasConcept C2778609137 @default.
- W4313382022 hasConcept C2780640218 @default.
- W4313382022 hasConcept C28328180 @default.
- W4313382022 hasConcept C2911091166 @default.
- W4313382022 hasConcept C502942594 @default.
- W4313382022 hasConcept C529278444 @default.
- W4313382022 hasConcept C55493867 @default.
- W4313382022 hasConcept C71924100 @default.
- W4313382022 hasConcept C86803240 @default.
- W4313382022 hasConcept C87753298 @default.
- W4313382022 hasConcept C8891405 @default.
- W4313382022 hasConcept C95444343 @default.
- W4313382022 hasConceptScore W4313382022C104317684 @default.
- W4313382022 hasConceptScore W4313382022C107459253 @default.
- W4313382022 hasConceptScore W4313382022C124964019 @default.
- W4313382022 hasConceptScore W4313382022C126322002 @default.
- W4313382022 hasConceptScore W4313382022C136834591 @default.
- W4313382022 hasConceptScore W4313382022C145103041 @default.
- W4313382022 hasConceptScore W4313382022C169760540 @default.
- W4313382022 hasConceptScore W4313382022C202751555 @default.
- W4313382022 hasConceptScore W4313382022C203014093 @default.
- W4313382022 hasConceptScore W4313382022C2776914184 @default.
- W4313382022 hasConceptScore W4313382022C2777619251 @default.
- W4313382022 hasConceptScore W4313382022C2778486448 @default.
- W4313382022 hasConceptScore W4313382022C2778531937 @default.
- W4313382022 hasConceptScore W4313382022C2778609137 @default.
- W4313382022 hasConceptScore W4313382022C2780640218 @default.
- W4313382022 hasConceptScore W4313382022C28328180 @default.
- W4313382022 hasConceptScore W4313382022C2911091166 @default.
- W4313382022 hasConceptScore W4313382022C502942594 @default.
- W4313382022 hasConceptScore W4313382022C529278444 @default.
- W4313382022 hasConceptScore W4313382022C55493867 @default.
- W4313382022 hasConceptScore W4313382022C71924100 @default.
- W4313382022 hasConceptScore W4313382022C86803240 @default.
- W4313382022 hasConceptScore W4313382022C87753298 @default.
- W4313382022 hasConceptScore W4313382022C8891405 @default.
- W4313382022 hasConceptScore W4313382022C95444343 @default.
- W4313382022 hasIssue "1_Supplement" @default.
- W4313382022 hasLocation W43133820221 @default.
- W4313382022 hasOpenAccess W4313382022 @default.
- W4313382022 hasPrimaryLocation W43133820221 @default.
- W4313382022 hasRelatedWork W1578690717 @default.
- W4313382022 hasRelatedWork W1607206274 @default.
- W4313382022 hasRelatedWork W2030707538 @default.
- W4313382022 hasRelatedWork W2062521126 @default.
- W4313382022 hasRelatedWork W2563298675 @default.
- W4313382022 hasRelatedWork W3007845466 @default.
- W4313382022 hasRelatedWork W4297265645 @default.
- W4313382022 hasRelatedWork W4313382022 @default.
- W4313382022 hasRelatedWork W4319433888 @default.
- W4313382022 hasRelatedWork W3126160457 @default.
- W4313382022 hasVolume "198" @default.
- W4313382022 isParatext "false" @default.
- W4313382022 isRetracted "false" @default.
- W4313382022 workType "article" @default.