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- W4313382024 abstract "Abstract Alternatively activated macrophages (M2 MΦ) function to dampen host inflammatory responses and promote wound healing and tissue repair. As the blood brain barrier (BBB) restricts the flow of cells into the brain, understanding how M2 MΦ extravagate into the central nervous system (CNS) is of great interest. In a mouse model of neurocysticercosis (NCC) we previously demonstrated that M2 MΦ are essential in containing neuropathology in helminth infected CNS. Analysis of helminth infected mice revealed an abundant expression of galectin-7 that recognize galactose moieties in brain endothelial cells. The Galectin-7−/− NCC mice displayed a reduced accumulation of M2 MΦ in parasite infected brain. This reduction in M2 MΦ numbers in the CNS was correlated with an increased neuropathology and shortened survival. The use of adoptive transfer of fluorescent labeled cells demonstrated a decreased influx of M2 MΦ into the CNS of helminth infected NCC brains. The use of in-vitro transmigration assay conclusively demonstrated a key function of Galectin-7 expressed on endothelial cells in centrally regulating M2 MΦ entry into the CNS." @default.
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- W4313382024 date "2017-05-01" @default.
- W4313382024 modified "2023-09-23" @default.
- W4313382024 title "Galectin-7 regulates infiltration of alternatively activated macrophages into the central nervous system" @default.
- W4313382024 doi "https://doi.org/10.4049/jimmunol.198.supp.143.4" @default.
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