Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313382029> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313382029 endingPage "216.11" @default.
- W4313382029 startingPage "216.11" @default.
- W4313382029 abstract "Abstract The cecum is the main site where poultry are asymptomatically colonized by thermophillic Campylobacter spp. Consumption of contaminated poultry products is one of the main sources of human campylobacteriosis, for which Campylobacter jejuni is responsible for approximately 90% of the cases. In chickens, experimental models of C. jejuni colonization to examine the host-response have been established, but a model remains to be developed for commercial turkeys. We sought to develop a model to characterize intestinal colonization and host response in commercial turkeys using mutants of C. jejuni (strain NCTC 11168) constructed to express different antibiotic resistance markers (chloramphenicol (CjCm) or kanamycin (CjK)). Turkey poults were colonized by oral gavage at 21 days of age with up to 5×108 cfu of either CjCm, CjK or sterile PBS. Up to 8 poults/treatment were euthanized at days 2, 7 and 14 post-exposure and intestinal samples were assessed for colonization and host-response. Both mutants were consistently recovered from cecum, but not ileum, throughout the study, with ~107 cfu/g detected from cecal contents at day 14 post-exposure. Mild inflammatory changes were histologically noted in the cecum and cecal tonsil of CjCm or CjK colonized poults at days 7 and 14 post-exposure. Using IHC, Campylobacter antigen was detected between cecal villi by day 7, indicating persistent colonization. Host-response for cytokines (IL-6, -8, -10, -17A, -22 and others) and β-defensins was analyzed by qRT-PCR from intestinal tissues. This study demonstrates that CjCm and CjK persistently colonize the cecum of commercial turkeys and will be useful to evaluate strategies to reduce intestinal colonization by C. jejuni in turkeys and promote food safety." @default.
- W4313382029 created "2023-01-06" @default.
- W4313382029 creator A5021357859 @default.
- W4313382029 creator A5060449666 @default.
- W4313382029 creator A5078767515 @default.
- W4313382029 creator A5083279403 @default.
- W4313382029 creator A5086172106 @default.
- W4313382029 date "2017-05-01" @default.
- W4313382029 modified "2023-09-27" @default.
- W4313382029 title "Development of an experimental model of <i>Campylobacter jejuni</i> intestinal colonization in commercial turkeys" @default.
- W4313382029 doi "https://doi.org/10.4049/jimmunol.198.supp.216.11" @default.
- W4313382029 hasPublicationYear "2017" @default.
- W4313382029 type Work @default.
- W4313382029 citedByCount "0" @default.
- W4313382029 crossrefType "journal-article" @default.
- W4313382029 hasAuthorship W4313382029A5021357859 @default.
- W4313382029 hasAuthorship W4313382029A5060449666 @default.
- W4313382029 hasAuthorship W4313382029A5078767515 @default.
- W4313382029 hasAuthorship W4313382029A5083279403 @default.
- W4313382029 hasAuthorship W4313382029A5086172106 @default.
- W4313382029 hasConcept C134018914 @default.
- W4313382029 hasConcept C18903297 @default.
- W4313382029 hasConcept C189506811 @default.
- W4313382029 hasConcept C2776927270 @default.
- W4313382029 hasConcept C2776957140 @default.
- W4313382029 hasConcept C2777226302 @default.
- W4313382029 hasConcept C2777507495 @default.
- W4313382029 hasConcept C2777858656 @default.
- W4313382029 hasConcept C2779910956 @default.
- W4313382029 hasConcept C523546767 @default.
- W4313382029 hasConcept C54355233 @default.
- W4313382029 hasConcept C86803240 @default.
- W4313382029 hasConcept C89423630 @default.
- W4313382029 hasConceptScore W4313382029C134018914 @default.
- W4313382029 hasConceptScore W4313382029C18903297 @default.
- W4313382029 hasConceptScore W4313382029C189506811 @default.
- W4313382029 hasConceptScore W4313382029C2776927270 @default.
- W4313382029 hasConceptScore W4313382029C2776957140 @default.
- W4313382029 hasConceptScore W4313382029C2777226302 @default.
- W4313382029 hasConceptScore W4313382029C2777507495 @default.
- W4313382029 hasConceptScore W4313382029C2777858656 @default.
- W4313382029 hasConceptScore W4313382029C2779910956 @default.
- W4313382029 hasConceptScore W4313382029C523546767 @default.
- W4313382029 hasConceptScore W4313382029C54355233 @default.
- W4313382029 hasConceptScore W4313382029C86803240 @default.
- W4313382029 hasConceptScore W4313382029C89423630 @default.
- W4313382029 hasIssue "1_Supplement" @default.
- W4313382029 hasLocation W43133820291 @default.
- W4313382029 hasOpenAccess W4313382029 @default.
- W4313382029 hasPrimaryLocation W43133820291 @default.
- W4313382029 hasRelatedWork W109150655 @default.
- W4313382029 hasRelatedWork W1490543040 @default.
- W4313382029 hasRelatedWork W2030833878 @default.
- W4313382029 hasRelatedWork W2137192848 @default.
- W4313382029 hasRelatedWork W2151150808 @default.
- W4313382029 hasRelatedWork W2501038401 @default.
- W4313382029 hasRelatedWork W2746217553 @default.
- W4313382029 hasRelatedWork W2790965249 @default.
- W4313382029 hasRelatedWork W2919042307 @default.
- W4313382029 hasRelatedWork W4313382029 @default.
- W4313382029 hasVolume "198" @default.
- W4313382029 isParatext "false" @default.
- W4313382029 isRetracted "false" @default.
- W4313382029 workType "article" @default.