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- W4313382034 startingPage "220.19" @default.
- W4313382034 abstract "Abstract Asthma is an increasingly common chronic inflammatory airway disorder with phenotypic heterogeneity driven by age, gender, atopy, lung function, lifestyle, body mass indexes, and the underlying cellular and molecular pathways. In asthma, T helper (Th) cells drive inflammatory cascades via cytokine/inflammatory mediators and recruit leukocytes into the airway. While treatments are available, such as inhaled corticosteroids, individuals with severe asthma are often steroid resistant and have a poor quality of life. It is therefore important to develop our understanding of the underlying T cell driven mechanisms leading to pulmonary inflammation such that novel therapies may be developed. Previous work from our lab has demonstrated the importance of commensal microbiota in the development and maintenance of peripheral homeostasis. Exposure to bacterial polysaccharides, such as PSA from Bacteroides fragilis, inhibits Th1 and Th2 activity in murine models by activation of CD4+ FoxP3− CD45Rblo CD62Llo CD44hi T effector memory (Rblo Tem) cells in an IL-10 dependent fashion. Here, we show that activated Rblo Tem cells can reverse established pulmonary inflammatory disease in a murine house dust mite (HDM) model. Adoptive transfer of these cells nearly eliminates lung pathology and severely limits tissue infiltration by leukocytes. These results provide a rationale for the use of autologous cell transfer as a means to prevent and reverse ongoing inflammatory lung disease." @default.
- W4313382034 created "2023-01-06" @default.
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- W4313382034 date "2017-05-01" @default.
- W4313382034 modified "2023-09-24" @default.
- W4313382034 title "Amelioration of pulmonary inflammation through T cell activation in murine asthma model" @default.
- W4313382034 doi "https://doi.org/10.4049/jimmunol.198.supp.220.19" @default.
- W4313382034 hasPublicationYear "2017" @default.
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