Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313382046> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313382046 endingPage "201.14" @default.
- W4313382046 startingPage "201.14" @default.
- W4313382046 abstract "Abstract P2Y10, along with GPR34 and GPR174, is a G protein-coupled receptor that is activated by lysophosphatidylserine (LysoPS), and its expression and function have not yet been described. We have previously shown that P2Y10 is one of the highly upregulated genes at the late differentiation stage during in vitro eosinophilopoiesis. In the present study, we examine the expression and functions of P2Y10 in human eosinophils. P2Y10 is increasingly expressed, as cord blood (CB) CD34+ cells differentiate toward eosinophils. Analysis of its expression in peripheral blood (PB) leukocytes shows that P2Y10 is the most highly expressed in the granulocytes among the major leukocytes in numbers, including lymphocytes, monocytes, and granulocytes. Importantly, PB eosinophils express this receptor much more strongly than PB neutrophils. In contrast, GPR34 and GPR174 are negligible on PB eosinophils, while being comparable to P2Y10 in PB neutrophils. LysoPS activates CB eosinophils to induce a robust ERK phosphorylation as profoundly as IL-5. LysoPS is able to trigger degranulation of eosinophil cationic protein (ECP) in PB eosinophils, and its capability of degranulation is significantly blocked by inhibitors of signaling or receptor molecules including ERK, TACE, and EGFR. Taken together, our data suggest that LysoPS provokes a proinflammatory functions of eosinophils likely through P2Y10, proposing P2Y10 as a potential therapeutic target to control eosinophil-associated diseases." @default.
- W4313382046 created "2023-01-06" @default.
- W4313382046 creator A5000529423 @default.
- W4313382046 creator A5002464127 @default.
- W4313382046 creator A5086749040 @default.
- W4313382046 date "2017-05-01" @default.
- W4313382046 modified "2023-10-16" @default.
- W4313382046 title "Identification of lysophosphatidylserine receptor P2Y10 as a novel G-protein coupled receptor mediating eosinophil degranulation" @default.
- W4313382046 doi "https://doi.org/10.4049/jimmunol.198.supp.201.14" @default.
- W4313382046 hasPublicationYear "2017" @default.
- W4313382046 type Work @default.
- W4313382046 citedByCount "0" @default.
- W4313382046 crossrefType "journal-article" @default.
- W4313382046 hasAuthorship W4313382046A5000529423 @default.
- W4313382046 hasAuthorship W4313382046A5002464127 @default.
- W4313382046 hasAuthorship W4313382046A5086749040 @default.
- W4313382046 hasConcept C104317684 @default.
- W4313382046 hasConcept C127561419 @default.
- W4313382046 hasConcept C153911025 @default.
- W4313382046 hasConcept C170493617 @default.
- W4313382046 hasConcept C185592680 @default.
- W4313382046 hasConcept C203014093 @default.
- W4313382046 hasConcept C2776042228 @default.
- W4313382046 hasConcept C2777037409 @default.
- W4313382046 hasConcept C2777983669 @default.
- W4313382046 hasConcept C2993002077 @default.
- W4313382046 hasConcept C49802076 @default.
- W4313382046 hasConcept C55493867 @default.
- W4313382046 hasConcept C86803240 @default.
- W4313382046 hasConcept C88675164 @default.
- W4313382046 hasConcept C95444343 @default.
- W4313382046 hasConceptScore W4313382046C104317684 @default.
- W4313382046 hasConceptScore W4313382046C127561419 @default.
- W4313382046 hasConceptScore W4313382046C153911025 @default.
- W4313382046 hasConceptScore W4313382046C170493617 @default.
- W4313382046 hasConceptScore W4313382046C185592680 @default.
- W4313382046 hasConceptScore W4313382046C203014093 @default.
- W4313382046 hasConceptScore W4313382046C2776042228 @default.
- W4313382046 hasConceptScore W4313382046C2777037409 @default.
- W4313382046 hasConceptScore W4313382046C2777983669 @default.
- W4313382046 hasConceptScore W4313382046C2993002077 @default.
- W4313382046 hasConceptScore W4313382046C49802076 @default.
- W4313382046 hasConceptScore W4313382046C55493867 @default.
- W4313382046 hasConceptScore W4313382046C86803240 @default.
- W4313382046 hasConceptScore W4313382046C88675164 @default.
- W4313382046 hasConceptScore W4313382046C95444343 @default.
- W4313382046 hasIssue "1_Supplement" @default.
- W4313382046 hasLocation W43133820461 @default.
- W4313382046 hasOpenAccess W4313382046 @default.
- W4313382046 hasPrimaryLocation W43133820461 @default.
- W4313382046 hasRelatedWork W1997801127 @default.
- W4313382046 hasRelatedWork W2038365817 @default.
- W4313382046 hasRelatedWork W2071471366 @default.
- W4313382046 hasRelatedWork W2086913569 @default.
- W4313382046 hasRelatedWork W2161987384 @default.
- W4313382046 hasRelatedWork W2554319862 @default.
- W4313382046 hasRelatedWork W2598804597 @default.
- W4313382046 hasRelatedWork W2792600017 @default.
- W4313382046 hasRelatedWork W2796024557 @default.
- W4313382046 hasRelatedWork W4313382046 @default.
- W4313382046 hasVolume "198" @default.
- W4313382046 isParatext "false" @default.
- W4313382046 isRetracted "false" @default.
- W4313382046 workType "article" @default.