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- W4313382080 abstract "Abstract Since osteoclast plays a key role in bone resorption, the identification of novel molecules that regulate osteoclastogenesis has been important issue. A neurokine or brain-specific chemokine, FAM19A5, a member of C-C chemokine family, is mainly expressed in central nervous system. In this study, we found that FAM19A5 strongly stimulated chemotactic migration of mouse bone marrow-derived macrophages (BMDM). FAM19A5 also markedly stimulated the activation of protein kinase B (Akt) and ERK, resulting in phosphorylation of the kinases in BMDM. FAM19A5 also blocks RANKL-induced osteoclastogenesis. It was confirmed by tartrate-resistant acid phosphatase (TRAP) staining and osteoclast-related gene level. Collectively, we suggest that FAM19A5 can act as a new ligand that regulates chemotactic migration of BMDM and osteoclastogenesis." @default.
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- W4313382080 date "2017-05-01" @default.
- W4313382080 modified "2023-09-27" @default.
- W4313382080 title "A brain-specific chemokine, FAM19A5, inhibits RANKL-induced osteoclast formation" @default.
- W4313382080 doi "https://doi.org/10.4049/jimmunol.198.supp.221.13" @default.
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