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- W4313382135 abstract "Abstract The central nervous system (CNS) is classically viewed as an immune privileged site; however recent advances in the field highlight the importance between the interaction of the peripheral immune system and the CNS in maintaining tissue homeostasis. Tissue resident memory (Trm) CD8 T cells have been described in almost every organ and are shown to provide a first line of defense against secondary invading pathogens. Trm cell generation generally involves active infection at the site of tissue residence. Using multicolor flow cytometry and 2-photon microscopy, we describe a population of CD8 T cells isolated from the CNS after peripheral systemic infections. At an effector time point, intravascular (IV) stain negative antigen-specific cells isolated from the CNS express high levels of chemokine receptors CXCR6 and CXCR3, adhesion molecules CD11a and CD49a and the Trm marker CD69. This CD8 population acquires CD103 expression and persists long term. Peripherally-induced CNS CD8 T cells are highly dynamic both inside and outside the blood vessels. Within the blood vessels, CD8 T cells can be seen flowing free, sticking to the walls of the vessels and crawling along the blood vessels with and against the flow of blood. Outside the vessels, CD8 T cells are seen surveying the tissue with multiple mechanisms including moving along the blood vessels, traveling long distances in apparently random fashion or remaining stationary. The purpose of systemically-induced Trm-like CD8 T cell populations remains to be determined; however, it is possible that that these cells are similar to conventionally-derived Trm populations and may provide the first line of defense should an invading pathogen reach the CNS." @default.
- W4313382135 created "2023-01-06" @default.
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- W4313382135 date "2018-05-01" @default.
- W4313382135 modified "2023-10-16" @default.
- W4313382135 title "CD8 T cells are recruited to the central nervous system after peripheral infections and adopt a tissue resident memory phenotype" @default.
- W4313382135 doi "https://doi.org/10.4049/jimmunol.200.supp.102.18" @default.
- W4313382135 hasPublicationYear "2018" @default.
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