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- W4313382181 startingPage "202.17" @default.
- W4313382181 abstract "Abstract Neutrophils and eosinophils, the two prominent granulocytes in circulation, are characteristically distinguished by neutrophil primary granule proteins (NPGPs) and eosinophil specific granule proteins (ESGPs). They differentiate from myeloid progenitors in the bone marrow commonly through a successive stage encompassing promyelocyte, myelocyte, metamyelocyte, and band form. The purpose of this study is to analyze bifurcation of the two granulocytes by examining expression of the NPGP- and ESGP-encoding genes during eosinophilic differentiation of cord blood (CB) CD34+ cells for 24 days. All transcripts of the NPGP-encoding genes, including PRTN3, MPO, CTSG, AZU1, and ELANE, reach peaks at day 12 and steeply decrease thereafter, while the transcripts of ESGP-encoding genes, such as MBP and ECP, reached peaks at day 18. Similarly, upon differentiation of immature eosinophilic EoL-1 cells, the NPGP transcripts are markedly downregulated accompanying by upregulated ESGP transcripts. Thus, the NPGP-encoding genes appear to be transcriptionally active even at eosinophilic promyelocyte and myelocyte stages. As these cells undergo maturation through metamyelocyte and band form stages, a transcription network come into a play that favorably shifts expression the ESGP-encoding genes." @default.
- W4313382181 created "2023-01-06" @default.
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- W4313382181 date "2017-05-01" @default.
- W4313382181 modified "2023-10-16" @default.
- W4313382181 title "Analysis of expression of genes encoding neutrophil and eosinophil granule proteins during in vitro eosinophilopoiesis" @default.
- W4313382181 doi "https://doi.org/10.4049/jimmunol.198.supp.202.17" @default.
- W4313382181 hasPublicationYear "2017" @default.
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