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- W4313382212 abstract "Abstract Acinetobacter baumannii is an increasing cause of hospital-acquired infections and a prominent cause of combat-related infections in the Middle East. Infections with this bacterium lead to a TLR4 response that initiates a potent innate immune response. Bacterial coinfection may occur in hospitalized patients, and endotoxin (LPS) released from one Gram-negative bacterium may have profound effects on pathogenesis of other co-infecting bacteria. Specifically, LPS induced oxidative stress has a significant impact on mucosal barrier function, leading to enhanced permeability and bacterial translocation. To delineate the importance of LPS in E. coli and Ab coinfection, we utilized a murine model of pulmonary Ab infection with oxidative stress induced via LPS injection. While the bacterial factors involved in translocation under oxidative stress are largely unknown, one plausible factor, based on previous research in our lab, is thioredoxin. Thioredoxin-1 (Trx1/TrxA) is a member of the thioredoxin protein superfamily that can be reversibly oxidized and reduced to facilitate reduction of disulfide bonds, as well as for protecting against free-radical damage. Our lab has created a mutant of Ab Clinical isolate 79 (Ci79) that lacks thioredoxin-1 (ΔTrxA). Using this mutant, the effects of thioredoxin on bacterial translocation during oxidative stress can be determined. Mice given E. coli LPS showed significantly increased translocation of Ci79 via organ burden. Mice infected with ΔTrxA showed significantly less translocation than the WT strains. Additionally, when Ci79 was treated with a TrxA blocker before infection, survival was increased and organ burden decreased." @default.
- W4313382212 created "2023-01-06" @default.
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- W4313382212 date "2017-05-01" @default.
- W4313382212 modified "2023-09-28" @default.
- W4313382212 title "Role of <i>Acinetobacter baumannii</i> thioredoxin in bacterial dissemination by modulation of mucosal oxidative homeostasis" @default.
- W4313382212 doi "https://doi.org/10.4049/jimmunol.198.supp.216.9" @default.
- W4313382212 hasPublicationYear "2017" @default.
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