Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313382695> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313382695 endingPage "70.19" @default.
- W4313382695 startingPage "70.19" @default.
- W4313382695 abstract "Abstract Neutrophils are typically considered short-lived and terminally differentiated. However, recent studies have identified a poorly understood neutrophil subset that can differentiate into dendritic cells and become long-lasting “hybrids” of neutrophils and dendritic cells. These neutrophil-dendritic cells (PMN-DCs) maintain the functions of canonical neutrophils while gaining antigen-presenting properties of dendritic cells, enabling them to contribute to both innate and adaptive immunity. Although PMN-DCs have been characterized in various inflammatory conditions, the cues that drive their development are not fully understood. Granulocyte macrophage colony-stimulating factor (GM-CSF) has previously been implicated as an important signal for PMN-DC development in studies of murine and human neutrophils. In vivo neutralization suggests that GM-CSF is sufficient but not necessary to drive PMN-DC differentiation. To determine the requirement of GM-CSF we have deleted GM-CSF receptor using CRISPR editing of a murine neutrophil progenitor cell line. We have tested other implicated cytokines in vitro, including IL-3, IL-4, TNF-α and IFN-γ, however these signals alone do not induce differentiation of PMN-DCs but can augment or blunt PMN-DC differentiation. Previous work shows that PMN-DCs are potent effectors of antifungal immunity through both direct killing and antigen presentation; understanding of the developmental signals that drive PMN-DC differentiation is essential for any future therapies targeting PMN-DCs." @default.
- W4313382695 created "2023-01-06" @default.
- W4313382695 creator A5003598305 @default.
- W4313382695 creator A5010768212 @default.
- W4313382695 creator A5054123162 @default.
- W4313382695 creator A5088333696 @default.
- W4313382695 creator A5088797237 @default.
- W4313382695 date "2019-05-01" @default.
- W4313382695 modified "2023-09-27" @default.
- W4313382695 title "Defining the signaling and downstream regulation of neutrophil-dendritic cell development for adjunctive therapy" @default.
- W4313382695 doi "https://doi.org/10.4049/jimmunol.202.supp.70.19" @default.
- W4313382695 hasPublicationYear "2019" @default.
- W4313382695 type Work @default.
- W4313382695 citedByCount "0" @default.
- W4313382695 crossrefType "journal-article" @default.
- W4313382695 hasAuthorship W4313382695A5003598305 @default.
- W4313382695 hasAuthorship W4313382695A5010768212 @default.
- W4313382695 hasAuthorship W4313382695A5054123162 @default.
- W4313382695 hasAuthorship W4313382695A5088333696 @default.
- W4313382695 hasAuthorship W4313382695A5088797237 @default.
- W4313382695 hasConcept C136449434 @default.
- W4313382695 hasConcept C193419808 @default.
- W4313382695 hasConcept C201750760 @default.
- W4313382695 hasConcept C203014093 @default.
- W4313382695 hasConcept C2776090121 @default.
- W4313382695 hasConcept C2778170410 @default.
- W4313382695 hasConcept C28328180 @default.
- W4313382695 hasConcept C51785407 @default.
- W4313382695 hasConcept C83464605 @default.
- W4313382695 hasConcept C86803240 @default.
- W4313382695 hasConcept C8891405 @default.
- W4313382695 hasConcept C95444343 @default.
- W4313382695 hasConceptScore W4313382695C136449434 @default.
- W4313382695 hasConceptScore W4313382695C193419808 @default.
- W4313382695 hasConceptScore W4313382695C201750760 @default.
- W4313382695 hasConceptScore W4313382695C203014093 @default.
- W4313382695 hasConceptScore W4313382695C2776090121 @default.
- W4313382695 hasConceptScore W4313382695C2778170410 @default.
- W4313382695 hasConceptScore W4313382695C28328180 @default.
- W4313382695 hasConceptScore W4313382695C51785407 @default.
- W4313382695 hasConceptScore W4313382695C83464605 @default.
- W4313382695 hasConceptScore W4313382695C86803240 @default.
- W4313382695 hasConceptScore W4313382695C8891405 @default.
- W4313382695 hasConceptScore W4313382695C95444343 @default.
- W4313382695 hasIssue "1_Supplement" @default.
- W4313382695 hasLocation W43133826951 @default.
- W4313382695 hasOpenAccess W4313382695 @default.
- W4313382695 hasPrimaryLocation W43133826951 @default.
- W4313382695 hasRelatedWork W1983365509 @default.
- W4313382695 hasRelatedWork W1988170203 @default.
- W4313382695 hasRelatedWork W2047073144 @default.
- W4313382695 hasRelatedWork W2047588363 @default.
- W4313382695 hasRelatedWork W2050843827 @default.
- W4313382695 hasRelatedWork W2081650874 @default.
- W4313382695 hasRelatedWork W2088497283 @default.
- W4313382695 hasRelatedWork W2092646329 @default.
- W4313382695 hasRelatedWork W2138831809 @default.
- W4313382695 hasRelatedWork W2155850103 @default.
- W4313382695 hasVolume "202" @default.
- W4313382695 isParatext "false" @default.
- W4313382695 isRetracted "false" @default.
- W4313382695 workType "article" @default.