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- W4313382907 abstract "Abstract Inflammasome activation induced by microbial components leads to an effective innate immune response. Bacillus anthracis is able to induce activation of the NLRP1b inflammasome, whereas B. cereus can induce activation of the NLRP3 inflammasome. However, whether different strains of B. cereus have differential ability to induce activation of the inflammasome has not been investigated. Further, whether other members of the Bacillus genus can induce activation of the inflammasome has remained unknown. Here, we screened 46 B. cereus strains from environmental and clinical sources to determine whether novel inflammasomes are activated. We infected primary mouse bone marrow-derived macrophages with bacteria or bacteria-free supernatant and observed for pyroptosis and other classical features of inflammasome activation. Strikingly, over 90% (42/46) of the B. cereus strains induced inflammasome activation as measured by caspase-1 cleavage and robust secretion of IL-1b, IL-18 and LDH. We identified that the inflammasome sensor NLRP3 was necessary to drive this response. Further, we confirmed that HBL and/or NHE toxins were expressed in all 42 B. cereus strains, suggesting a conserved inflammasome activation pattern amongst B. cereus strains. We also identified that four pathogenic Bacillus species induced inflammasome activation in an NLRP3-dependent manner, including B. idriensis, B. mycoides, B. pseudomycoides and B. thurigiensis. These findings highlight that the NLRP3 inflammasome sensor is important for immune recognition of several Bacillus species and suggest that therapeutic modulation of NLRP3 may enhance host protection against these Bacillus infections." @default.
- W4313382907 created "2023-01-06" @default.
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- W4313382907 creator A5042683783 @default.
- W4313382907 creator A5091476985 @default.
- W4313382907 date "2020-05-01" @default.
- W4313382907 modified "2023-09-27" @default.
- W4313382907 title "Inflammasome activation by members of the <i>Bacillus</i> genus" @default.
- W4313382907 doi "https://doi.org/10.4049/jimmunol.204.supp.68.21" @default.
- W4313382907 hasPublicationYear "2020" @default.
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