Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383016> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313383016 endingPage "183.21" @default.
- W4313383016 startingPage "183.21" @default.
- W4313383016 abstract "Abstract CCR6 is important for imiquimod (IMQ)-induced psoriatic dermatitis in mice, which depends on motile CCR6+ γδ T cells that produce IL-17 and IL-22. CCR6 ligands include CCL20 and β-defensins. We used new strains of Ccl20 tdTomato knock-in mice, Ccl20fl/flmice, and Ccr6fl/fl GFP knock-in mice to determine sites of production and action of CCL20 and its role in the localization of γδ T cells and ILCs during imiquimod (IMQ)-induced inflammation. IMQ treatment of Ccl20+/tdT mice led to expression of Ccl20 in keratinocytes (KCs), including in the infundibulum and isthmus of the hair follicles. Ccl20−/− mice showed reduced inflammation and expression of Il17 and Il22 in the treated skin. Deletion of Ccl20 specifically in the KCs by treating Ccl20fl/flK14-CreERT mice with tamoxifen before applying IMQ significantly decreased the accumulation of IL-17-producing gd T cells and ILCs in the epidermis. Depleting KC-derived CCL20 at day 4 when inflammation was well established also reduced the number of epidermal γδ T cells and ILCs. In both cases the percent of IL-17-producing γδ T cells and ILCs did not change, demonstrating that migration to the epidermis and the ability to produce IL-17 are regulated independently. Multi-photon microscopy of IMQ-treated Ccr6+/gfp and Ccr6gfp/gfp(CCR6-deficient) micerevealed a CCR6-independent step whereby dermal CCR6+ cells accumulate at the hair follicles, followed by a CCR6-dependent step whereby the cells move into the superficial epidermis." @default.
- W4313383016 created "2023-01-06" @default.
- W4313383016 creator A5015969131 @default.
- W4313383016 creator A5037176858 @default.
- W4313383016 creator A5038241088 @default.
- W4313383016 creator A5044389462 @default.
- W4313383016 creator A5049464184 @default.
- W4313383016 creator A5053081399 @default.
- W4313383016 creator A5058411478 @default.
- W4313383016 date "2019-05-01" @default.
- W4313383016 modified "2023-09-28" @default.
- W4313383016 title "Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation" @default.
- W4313383016 doi "https://doi.org/10.4049/jimmunol.202.supp.183.21" @default.
- W4313383016 hasPublicationYear "2019" @default.
- W4313383016 type Work @default.
- W4313383016 citedByCount "0" @default.
- W4313383016 crossrefType "journal-article" @default.
- W4313383016 hasAuthorship W4313383016A5015969131 @default.
- W4313383016 hasAuthorship W4313383016A5037176858 @default.
- W4313383016 hasAuthorship W4313383016A5038241088 @default.
- W4313383016 hasAuthorship W4313383016A5044389462 @default.
- W4313383016 hasAuthorship W4313383016A5049464184 @default.
- W4313383016 hasAuthorship W4313383016A5053081399 @default.
- W4313383016 hasAuthorship W4313383016A5058411478 @default.
- W4313383016 hasConcept C105702510 @default.
- W4313383016 hasConcept C12823836 @default.
- W4313383016 hasConcept C13373296 @default.
- W4313383016 hasConcept C203014093 @default.
- W4313383016 hasConcept C2776458125 @default.
- W4313383016 hasConcept C2776914184 @default.
- W4313383016 hasConcept C2777074287 @default.
- W4313383016 hasConcept C2778690821 @default.
- W4313383016 hasConcept C2779112978 @default.
- W4313383016 hasConcept C2780564577 @default.
- W4313383016 hasConcept C47348012 @default.
- W4313383016 hasConcept C50345908 @default.
- W4313383016 hasConcept C54355233 @default.
- W4313383016 hasConcept C74172505 @default.
- W4313383016 hasConcept C81885089 @default.
- W4313383016 hasConcept C83360876 @default.
- W4313383016 hasConcept C86803240 @default.
- W4313383016 hasConcept C94205230 @default.
- W4313383016 hasConcept C95444343 @default.
- W4313383016 hasConceptScore W4313383016C105702510 @default.
- W4313383016 hasConceptScore W4313383016C12823836 @default.
- W4313383016 hasConceptScore W4313383016C13373296 @default.
- W4313383016 hasConceptScore W4313383016C203014093 @default.
- W4313383016 hasConceptScore W4313383016C2776458125 @default.
- W4313383016 hasConceptScore W4313383016C2776914184 @default.
- W4313383016 hasConceptScore W4313383016C2777074287 @default.
- W4313383016 hasConceptScore W4313383016C2778690821 @default.
- W4313383016 hasConceptScore W4313383016C2779112978 @default.
- W4313383016 hasConceptScore W4313383016C2780564577 @default.
- W4313383016 hasConceptScore W4313383016C47348012 @default.
- W4313383016 hasConceptScore W4313383016C50345908 @default.
- W4313383016 hasConceptScore W4313383016C54355233 @default.
- W4313383016 hasConceptScore W4313383016C74172505 @default.
- W4313383016 hasConceptScore W4313383016C81885089 @default.
- W4313383016 hasConceptScore W4313383016C83360876 @default.
- W4313383016 hasConceptScore W4313383016C86803240 @default.
- W4313383016 hasConceptScore W4313383016C94205230 @default.
- W4313383016 hasConceptScore W4313383016C95444343 @default.
- W4313383016 hasIssue "1_Supplement" @default.
- W4313383016 hasLocation W43133830161 @default.
- W4313383016 hasOpenAccess W4313383016 @default.
- W4313383016 hasPrimaryLocation W43133830161 @default.
- W4313383016 hasRelatedWork W2015215849 @default.
- W4313383016 hasRelatedWork W2277216350 @default.
- W4313383016 hasRelatedWork W2514306162 @default.
- W4313383016 hasRelatedWork W2989482392 @default.
- W4313383016 hasRelatedWork W3181863490 @default.
- W4313383016 hasRelatedWork W3199561170 @default.
- W4313383016 hasRelatedWork W4281479908 @default.
- W4313383016 hasRelatedWork W4309479462 @default.
- W4313383016 hasRelatedWork W4309480387 @default.
- W4313383016 hasRelatedWork W4313383016 @default.
- W4313383016 hasVolume "202" @default.
- W4313383016 isParatext "false" @default.
- W4313383016 isRetracted "false" @default.
- W4313383016 workType "article" @default.