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- W4313383122 abstract "Abstract Although widely studied as a neurotransmitter, recent advances have revealed an important role for T-cell derived acetylcholine (ACh) in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4+ and CD8+ T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. Deletion of chat within the T-cell compartment ablated vasodilation in response to infection, impaired the migration of anti-viral T cells into infected tissues, and ultimately compromised the control of chronic LCMV-Cl13. Our results reveal a genetic proof-of-function for ChAT in T cells during viral infection and identify a pathway of T-cell migration that sustains anti-viral immunity." @default.
- W4313383122 created "2023-01-06" @default.
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- W4313383122 date "2019-05-01" @default.
- W4313383122 modified "2023-09-27" @default.
- W4313383122 title "Choline acetyltransferase-expressing T cells are required to control chronic viral infection" @default.
- W4313383122 doi "https://doi.org/10.4049/jimmunol.202.supp.117.17" @default.
- W4313383122 hasPublicationYear "2019" @default.
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