Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383301> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313383301 endingPage "73.12" @default.
- W4313383301 startingPage "73.12" @default.
- W4313383301 abstract "Abstract Immune related adverse events linked to severe inflammatory arthritis have been identified in 10–43% of patients receiving immune checkpoint inhibitor therapy, aCTLA-4, aPD-1 and aPD-L1, indicating the importance of immune inhibitory pathways in maintaining homeostasis in the synovium. We found that immune checkpoint, PD-L1, is primarily expressed in the joint compared to other immune checkpoints. Furthermore, blocking of PD-L1 during collagen induced arthritis (CIA) resulted in more severe arthritis. Mice synovial macrophages have the highest PD-L1 expression level at homeostasis and macrophage PD-L1 expression is further increased during CIA. Similarly, in human synovial fluid, macrophages have the highest frequency of PD-L1 expression. We hypothesize that the expression of PD-L1 by macrophages is essential for synovial homeostasis and regulation of joint inflammation. We selectively deleted PD-L1 in macrophages using the cre/flox system and induced CIA analyzing disease severity using flow cytometry. LyzcrePD-L1fl/fl showed more severe CIA with a greater change in paw thickness, higher disease and histology score and a higher frequency of CD4 and CD8 T cells in the synovium. Interestingly, female LyzcrePD-L1fl/fl mice have higher arthritis severity to LyzcrePD-L1fl/fl males. This indicates the importance of sex specific PD-L1 expression by synovial macrophages during CIA. Our project has high translational potential since joint specific PD-L1 expression could be modulated for therapeutic purposes in humans with rheumatoid arthritis or check point inhibitors induced arthritis." @default.
- W4313383301 created "2023-01-06" @default.
- W4313383301 creator A5005250476 @default.
- W4313383301 creator A5055145325 @default.
- W4313383301 creator A5057713838 @default.
- W4313383301 creator A5091135105 @default.
- W4313383301 date "2020-05-01" @default.
- W4313383301 modified "2023-09-27" @default.
- W4313383301 title "PD-L1 on macrophages protects from severe collagen induced arthritis" @default.
- W4313383301 doi "https://doi.org/10.4049/jimmunol.204.supp.73.12" @default.
- W4313383301 hasPublicationYear "2020" @default.
- W4313383301 type Work @default.
- W4313383301 citedByCount "0" @default.
- W4313383301 crossrefType "journal-article" @default.
- W4313383301 hasAuthorship W4313383301A5005250476 @default.
- W4313383301 hasAuthorship W4313383301A5055145325 @default.
- W4313383301 hasAuthorship W4313383301A5057713838 @default.
- W4313383301 hasAuthorship W4313383301A5091135105 @default.
- W4313383301 hasConcept C126322002 @default.
- W4313383301 hasConcept C142724271 @default.
- W4313383301 hasConcept C167672396 @default.
- W4313383301 hasConcept C202751555 @default.
- W4313383301 hasConcept C203014093 @default.
- W4313383301 hasConcept C204787440 @default.
- W4313383301 hasConcept C2776164576 @default.
- W4313383301 hasConcept C2776268809 @default.
- W4313383301 hasConcept C2776914184 @default.
- W4313383301 hasConcept C2777077863 @default.
- W4313383301 hasConcept C2777575956 @default.
- W4313383301 hasConcept C2777652487 @default.
- W4313383301 hasConcept C2779244956 @default.
- W4313383301 hasConcept C55493867 @default.
- W4313383301 hasConcept C63645605 @default.
- W4313383301 hasConcept C71924100 @default.
- W4313383301 hasConcept C86803240 @default.
- W4313383301 hasConcept C8891405 @default.
- W4313383301 hasConceptScore W4313383301C126322002 @default.
- W4313383301 hasConceptScore W4313383301C142724271 @default.
- W4313383301 hasConceptScore W4313383301C167672396 @default.
- W4313383301 hasConceptScore W4313383301C202751555 @default.
- W4313383301 hasConceptScore W4313383301C203014093 @default.
- W4313383301 hasConceptScore W4313383301C204787440 @default.
- W4313383301 hasConceptScore W4313383301C2776164576 @default.
- W4313383301 hasConceptScore W4313383301C2776268809 @default.
- W4313383301 hasConceptScore W4313383301C2776914184 @default.
- W4313383301 hasConceptScore W4313383301C2777077863 @default.
- W4313383301 hasConceptScore W4313383301C2777575956 @default.
- W4313383301 hasConceptScore W4313383301C2777652487 @default.
- W4313383301 hasConceptScore W4313383301C2779244956 @default.
- W4313383301 hasConceptScore W4313383301C55493867 @default.
- W4313383301 hasConceptScore W4313383301C63645605 @default.
- W4313383301 hasConceptScore W4313383301C71924100 @default.
- W4313383301 hasConceptScore W4313383301C86803240 @default.
- W4313383301 hasConceptScore W4313383301C8891405 @default.
- W4313383301 hasIssue "1_Supplement" @default.
- W4313383301 hasLocation W43133833011 @default.
- W4313383301 hasOpenAccess W4313383301 @default.
- W4313383301 hasPrimaryLocation W43133833011 @default.
- W4313383301 hasRelatedWork W1991393819 @default.
- W4313383301 hasRelatedWork W2016719252 @default.
- W4313383301 hasRelatedWork W2068097628 @default.
- W4313383301 hasRelatedWork W2098792606 @default.
- W4313383301 hasRelatedWork W2315485061 @default.
- W4313383301 hasRelatedWork W2618751246 @default.
- W4313383301 hasRelatedWork W3034396728 @default.
- W4313383301 hasRelatedWork W3137832197 @default.
- W4313383301 hasRelatedWork W322382848 @default.
- W4313383301 hasRelatedWork W4213218301 @default.
- W4313383301 hasVolume "204" @default.
- W4313383301 isParatext "false" @default.
- W4313383301 isRetracted "false" @default.
- W4313383301 workType "article" @default.