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- W4313383405 abstract "Abstract Idiopathic Thrombocytopenic Purpura (ITP) is a rare autoimmune disease which causes the destruction of platelets. Patients who suffer from ITP can have excessive bleeding due to a lack of platelet coagulation. Current therapies for ITP include steroid, and intravenous immunoglobulin treatment, however they do not guarantee lasting remission. Spleen removal is the only therapy that can lead to lasting remission but is very invasive and damaging to the patients. The purpose of this study is to find a more effective and permanent therapy to treat ITP, such as through bone marrow transplantation (BMT), in a novel mouse model of ITP. BMT can be a risky procedure, so we sought to first improve it by upregulating the important chemotactic receptor, CXCR4, on the surface of hematopoietic stem cells (HSCs). We can increase surface CXCR4 on HSCs by treatment with the glucocorticoid drug fluticasone propionate (Flonase), which increases migration towards the chemokine SDF-1. Our data indicate that after Flonase treatment, HSCs significantly increase bone marrow engraftment in mouse competitive transplantations. Second, we have created an inducible ITP mouse model using CRISPR technology to test BMT as a possible therapy for ITP. Our mouse model expresses foreign antigens ovalbumin and hen egg lysozyme on platelets to elicit an immune response and platelet destruction. A novel ITP mouse model can be useful for testing potentially more permanent therapies for ITP." @default.
- W4313383405 created "2023-01-06" @default.
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- W4313383405 date "2020-05-01" @default.
- W4313383405 modified "2023-09-28" @default.
- W4313383405 title "Improving Hematopoietic Stem Cell transplantation with Flonase for potential use in treating a novel mouse model of Idiopathic Thrombocytopenic Purpura" @default.
- W4313383405 doi "https://doi.org/10.4049/jimmunol.204.supp.238.19" @default.
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