Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383423> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313383423 endingPage "73.11" @default.
- W4313383423 startingPage "73.11" @default.
- W4313383423 abstract "Abstract Metabolic disorders, like atherosclerosis, increase the lipid burden in macrophages leading to chronic inflammation. How macrophages sense and respond to excess lipid is not well understood. Lipin-1 is a phosphatidic acid phosphatase that also functions as a transcriptional co-regulator and is critical to regulating lipid burden in cells. We have shown that lipin-1 enzymatic activity promotes macrophage pro-inflammatory responses and accelerates atherosclerosis. Lipin-1 transcriptional co-regulatory activity binds to and augments transcription factors such as PPARγ. PPARγ increases macrophage anti-inflammatory responses. The objective of this study was to determine if after increased lipid burden in macrophages, lipin-1 transcriptional co-regulatory activity tailors PPARγ to promote anti-inflammatory responses by macrophages and reduce atherosclerosis. Upon RNA analysis in lipid stimulated macrophages, we demonstrated lipin-1 tailors PPAR-associated gene expression and promotes anti-inflammatory responses. Using mice that lack just lipin-1 enzymatic activity or all lipin-1 in myeloid cells, we examined the contribution of lipin-1 transcriptional co-regulatory activity to atherosclerosis progression. Our mice lacking both myeloid-associated lipin-1 activities had larger, more necrotic plaques. Using Nanostring analysis, we observed increased expression of pro-inflammatory genes such as IL-23 in the plaque and increased IL-23 in serum suggesting lipin-1 transcriptional co-regulatory activity in macrophages promotes anti-inflammatory responses to reduce atherosclerosis. Our work highlights the dynamic nature of lipid metabolism on macrophage function and contribution to disease progression." @default.
- W4313383423 created "2023-01-06" @default.
- W4313383423 creator A5002840203 @default.
- W4313383423 creator A5011889982 @default.
- W4313383423 creator A5012554174 @default.
- W4313383423 creator A5044142721 @default.
- W4313383423 creator A5057879870 @default.
- W4313383423 date "2020-05-01" @default.
- W4313383423 modified "2023-09-27" @default.
- W4313383423 title "Lipin-1 transcriptional co-regulatory activity enhances anti-inflammatory responses in lipid-loaded macrophages and induces atheroprotection" @default.
- W4313383423 doi "https://doi.org/10.4049/jimmunol.204.supp.73.11" @default.
- W4313383423 hasPublicationYear "2020" @default.
- W4313383423 type Work @default.
- W4313383423 citedByCount "0" @default.
- W4313383423 crossrefType "journal-article" @default.
- W4313383423 hasAuthorship W4313383423A5002840203 @default.
- W4313383423 hasAuthorship W4313383423A5011889982 @default.
- W4313383423 hasAuthorship W4313383423A5012554174 @default.
- W4313383423 hasAuthorship W4313383423A5044142721 @default.
- W4313383423 hasAuthorship W4313383423A5057879870 @default.
- W4313383423 hasConcept C104317684 @default.
- W4313383423 hasConcept C127561419 @default.
- W4313383423 hasConcept C165864922 @default.
- W4313383423 hasConcept C170493617 @default.
- W4313383423 hasConcept C185592680 @default.
- W4313383423 hasConcept C187345961 @default.
- W4313383423 hasConcept C202751555 @default.
- W4313383423 hasConcept C203014093 @default.
- W4313383423 hasConcept C2776914184 @default.
- W4313383423 hasConcept C2777895019 @default.
- W4313383423 hasConcept C2779244956 @default.
- W4313383423 hasConcept C4733338 @default.
- W4313383423 hasConcept C502942594 @default.
- W4313383423 hasConcept C55493867 @default.
- W4313383423 hasConcept C86339819 @default.
- W4313383423 hasConcept C86803240 @default.
- W4313383423 hasConcept C95444343 @default.
- W4313383423 hasConceptScore W4313383423C104317684 @default.
- W4313383423 hasConceptScore W4313383423C127561419 @default.
- W4313383423 hasConceptScore W4313383423C165864922 @default.
- W4313383423 hasConceptScore W4313383423C170493617 @default.
- W4313383423 hasConceptScore W4313383423C185592680 @default.
- W4313383423 hasConceptScore W4313383423C187345961 @default.
- W4313383423 hasConceptScore W4313383423C202751555 @default.
- W4313383423 hasConceptScore W4313383423C203014093 @default.
- W4313383423 hasConceptScore W4313383423C2776914184 @default.
- W4313383423 hasConceptScore W4313383423C2777895019 @default.
- W4313383423 hasConceptScore W4313383423C2779244956 @default.
- W4313383423 hasConceptScore W4313383423C4733338 @default.
- W4313383423 hasConceptScore W4313383423C502942594 @default.
- W4313383423 hasConceptScore W4313383423C55493867 @default.
- W4313383423 hasConceptScore W4313383423C86339819 @default.
- W4313383423 hasConceptScore W4313383423C86803240 @default.
- W4313383423 hasConceptScore W4313383423C95444343 @default.
- W4313383423 hasIssue "1_Supplement" @default.
- W4313383423 hasLocation W43133834231 @default.
- W4313383423 hasOpenAccess W4313383423 @default.
- W4313383423 hasPrimaryLocation W43133834231 @default.
- W4313383423 hasRelatedWork W2535836989 @default.
- W4313383423 hasRelatedWork W2567103855 @default.
- W4313383423 hasRelatedWork W2587069137 @default.
- W4313383423 hasRelatedWork W2810856837 @default.
- W4313383423 hasRelatedWork W2903585292 @default.
- W4313383423 hasRelatedWork W3042041681 @default.
- W4313383423 hasRelatedWork W3206083060 @default.
- W4313383423 hasRelatedWork W3209749671 @default.
- W4313383423 hasRelatedWork W4313422237 @default.
- W4313383423 hasRelatedWork W4382344485 @default.
- W4313383423 hasVolume "204" @default.
- W4313383423 isParatext "false" @default.
- W4313383423 isRetracted "false" @default.
- W4313383423 workType "article" @default.