Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383457> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313383457 endingPage "110.7" @default.
- W4313383457 startingPage "110.7" @default.
- W4313383457 abstract "Abstract CD4+ T helper 17 (Th17) cells protect against pathogens at mucosal barriers by secreting cytokines that drive clearance of the pathogen by neutrophils. We found that Bcl6 interacting corepressor (BCOR) drives Th17 cell formation after Streptococcus pyogenes infection and was required for optimal expression of IL-17A and CCR6. RNA and chromatin immunoprecipitation sequencing revealed that BCOR enhances Th17 differentiation by directly repressing genes that negatively regulate Th17 cells, including genes related to the CD27 and Foxo1 signaling pathways. We have also found that Streptococcus infection generates a novel BCOR-driven Tfh-Th17 hybrid population, which may provide unique B cell help during mucosal infections. This work provides insight into a novel mechanism that enhances Th17 differentiation and function, which may be informative for the design of T cell based vaccines against extracellular pathogens at mucosal barriers." @default.
- W4313383457 created "2023-01-06" @default.
- W4313383457 creator A5007540366 @default.
- W4313383457 creator A5019712318 @default.
- W4313383457 creator A5078789855 @default.
- W4313383457 creator A5086851765 @default.
- W4313383457 date "2018-05-01" @default.
- W4313383457 modified "2023-09-27" @default.
- W4313383457 title "Bcl6 interacting corepressor contributes to CD4+ T helper 17 cell formation by repressing CD27 and Foxo1 signaling" @default.
- W4313383457 doi "https://doi.org/10.4049/jimmunol.200.supp.110.7" @default.
- W4313383457 hasPublicationYear "2018" @default.
- W4313383457 type Work @default.
- W4313383457 citedByCount "0" @default.
- W4313383457 crossrefType "journal-article" @default.
- W4313383457 hasAuthorship W4313383457A5007540366 @default.
- W4313383457 hasAuthorship W4313383457A5019712318 @default.
- W4313383457 hasAuthorship W4313383457A5078789855 @default.
- W4313383457 hasAuthorship W4313383457A5086851765 @default.
- W4313383457 hasConcept C101762097 @default.
- W4313383457 hasConcept C104317684 @default.
- W4313383457 hasConcept C134320426 @default.
- W4313383457 hasConcept C146777309 @default.
- W4313383457 hasConcept C150194340 @default.
- W4313383457 hasConcept C158448853 @default.
- W4313383457 hasConcept C159654299 @default.
- W4313383457 hasConcept C165864922 @default.
- W4313383457 hasConcept C203014093 @default.
- W4313383457 hasConcept C2776090121 @default.
- W4313383457 hasConcept C2777537477 @default.
- W4313383457 hasConcept C2778453870 @default.
- W4313383457 hasConcept C54355233 @default.
- W4313383457 hasConcept C62361671 @default.
- W4313383457 hasConcept C62478195 @default.
- W4313383457 hasConcept C86803240 @default.
- W4313383457 hasConcept C8891405 @default.
- W4313383457 hasConcept C95444343 @default.
- W4313383457 hasConcept C96926380 @default.
- W4313383457 hasConceptScore W4313383457C101762097 @default.
- W4313383457 hasConceptScore W4313383457C104317684 @default.
- W4313383457 hasConceptScore W4313383457C134320426 @default.
- W4313383457 hasConceptScore W4313383457C146777309 @default.
- W4313383457 hasConceptScore W4313383457C150194340 @default.
- W4313383457 hasConceptScore W4313383457C158448853 @default.
- W4313383457 hasConceptScore W4313383457C159654299 @default.
- W4313383457 hasConceptScore W4313383457C165864922 @default.
- W4313383457 hasConceptScore W4313383457C203014093 @default.
- W4313383457 hasConceptScore W4313383457C2776090121 @default.
- W4313383457 hasConceptScore W4313383457C2777537477 @default.
- W4313383457 hasConceptScore W4313383457C2778453870 @default.
- W4313383457 hasConceptScore W4313383457C54355233 @default.
- W4313383457 hasConceptScore W4313383457C62361671 @default.
- W4313383457 hasConceptScore W4313383457C62478195 @default.
- W4313383457 hasConceptScore W4313383457C86803240 @default.
- W4313383457 hasConceptScore W4313383457C8891405 @default.
- W4313383457 hasConceptScore W4313383457C95444343 @default.
- W4313383457 hasConceptScore W4313383457C96926380 @default.
- W4313383457 hasIssue "1_Supplement" @default.
- W4313383457 hasLocation W43133834571 @default.
- W4313383457 hasOpenAccess W4313383457 @default.
- W4313383457 hasPrimaryLocation W43133834571 @default.
- W4313383457 hasRelatedWork W1940806326 @default.
- W4313383457 hasRelatedWork W2012402949 @default.
- W4313383457 hasRelatedWork W2119300214 @default.
- W4313383457 hasRelatedWork W2567310309 @default.
- W4313383457 hasRelatedWork W2584619789 @default.
- W4313383457 hasRelatedWork W2737908377 @default.
- W4313383457 hasRelatedWork W2979894184 @default.
- W4313383457 hasRelatedWork W3129718514 @default.
- W4313383457 hasRelatedWork W3175205825 @default.
- W4313383457 hasRelatedWork W4313383457 @default.
- W4313383457 hasVolume "200" @default.
- W4313383457 isParatext "false" @default.
- W4313383457 isRetracted "false" @default.
- W4313383457 workType "article" @default.