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- W4313383510 abstract "Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF-2) plays an important role in regulating mature myeloid cell populations under both homeostatic and inflammatory conditions. GM-CSF maintains low basal levels under homeostatic conditions, but its levels can quickly become elevated during infection or inflammation. GM-CSF is rapidly produced during inflammatory or autoimmune reactions by a variety of cells, including endothelial cells, macrophages, dendritic cells (DCs), T cells, neutrophils, eosinophils, and more. It has been reported that the expression of GM-CSF is regulated by several transcription factors including NF-kB, AP-1, and RUNX1. Fli-1 belongs to the ETS transcription factor family. We have demonstrated that the Fli-1 transcription factor is a novel regulator in modulating the expression of many inflammatory mediators, including monocyte chemotactic protein 1 (MCP-1), chemokine (C-C motif) ligand 5 (CCL5) and interleukin 6 (IL-6). In this report, we found that murine endothelial cells transfected with Fli-1 specific siRNA produced significant lower levels of GM-CSF after stimulation with Toll-like receptor 4 ligand LPS compared to the cells transfected with control siRNA. Human primary glomerular endothelial cells transfected with Fli-1 specific siRNA had reduced Fli-1 protein and produced significantly less GM-CSF following LPS stimulation compared to the cells transfected with control siRNA. Transient transfection assays show that Fli-1 drives transcription from the GM-CSF promoter in a dose-dependent manner. Together, the results indicate that Fli-1 is a novel, critical transcription factor in regulating the expression of GM-CSF." @default.
- W4313383510 created "2023-01-06" @default.
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- W4313383510 date "2019-05-01" @default.
- W4313383510 modified "2023-09-27" @default.
- W4313383510 title "Expression of GM-CSF is regulated by transcription factor Fli-1" @default.
- W4313383510 doi "https://doi.org/10.4049/jimmunol.202.supp.181.3" @default.
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