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- W4313383567 abstract "Abstract Subunit vaccine development against some complex pathogens require inclusion of multiple targets to optimize efficacy and or broaden protection against diverse strains. To hasten vaccine development, it is rational to evaluate efficacy of a prototype vaccine in the actual outbred host that require protection. African Swine Fever Virus (ASFV) is a complex high-consequence Transboundary Animal Disease pathogen for which there is no vaccine or treatment available. Current evidence shows that protection against the ASFV can be stimulated with a vaccine since pigs that recover from infection with less virulent isolates are protected against closely related virulent isolates. In addition, there is evidence that ASFV-specific cytotoxic T lymphocytes (CTLs) are required for viral clearance. We have tested protective efficacy of several adenovirus-vectored prototype formulations containing multiple rationally selected ASFV antigens. Homologous prime-boost immunization of commercial pigs with one of the experimental vaccine induced significant and unprecedented antigen-specific CTL responses that were detectable in peripheral blood mononuclear cells (PBMCs). Significant IFN-gamma-secreting cells were also detected in PBMCs post-priming and the memory was recalled upon boost. In addition, the immunogen primed antibody responses that were recalled upon boost. More importantly, the prototype vaccine conferred protection in 5/9 of vaccinees following intranasal challenge with the ASFV Georgia 2007/1 isolate. Notably, these survivors were healthy with low clinical scores. In comparison, only 2/5 of the negative controls were alive 17 days post-challenge and they had high clinical scores that necessitated termination." @default.
- W4313383567 created "2023-01-06" @default.
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- W4313383567 date "2018-05-01" @default.
- W4313383567 modified "2023-10-06" @default.
- W4313383567 title "Efficacy of a Prototype Live-vectored Multi-antigen African Swine Fever Virus Vaccine" @default.
- W4313383567 doi "https://doi.org/10.4049/jimmunol.200.supp.59.10" @default.
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