Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383592> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4313383592 endingPage "107.15" @default.
- W4313383592 startingPage "107.15" @default.
- W4313383592 abstract "Abstract Atherosclerosis is a multifaceted chronic inflammatory disease characterized by the accumulation of modified low density lipoproteins (mLDL) and immune cells in the aortic wall leading to vascular dysfunction. Uptake of mLDL by macrophages (MF) and the formation of foam cells are key events in the induction of atherosclerosis. Our data shows that B cells can also uptake acetylated and oxidized LDL (acLDL and oxLDL, respectively), but the functional consequences of this uptake are currently not well-understood. The transcriptional profiles of sorted B cells that took up acLDL in vivo by RNAseq suggests that acLDL+ B cells assume a role distinct from MF, and reduces activation. Upon mLDL uptake, B cells dampen activating signaling molecule such as SYK, ERK, and BTK, but upregulate inhibitory signaling molecules such as phospho-Lyn (Tyr507). Importantly, the uptake of mLDL affects the ability of B cells to be activated both in vivo and in vitro. mLDL+ B cells mobilize less intracellular calcium in response to B cell receptor cross-linking. Additionally, after mLDL uptake, B cells are less efficient in response to TI-2 antigen DNP-Ficoll and B cells produce significantly lower levels of anti DNP-IgM Abs after the immunization. Upon several TLR stimulations B cells that took up acLDL also produce significantly less proinflammatory cytokines (IFN-g, IL-6). Together the results suggest that mLDL uptake by B cells results in an upregulation of threshold for B cell activation in pro-inflammatory atherosclerosis-prone conditions. Thus, the uptake of mLDL by B cells may play an unexpected protective role in atherosclerosis." @default.
- W4313383592 created "2023-01-06" @default.
- W4313383592 creator A5000483511 @default.
- W4313383592 creator A5004568835 @default.
- W4313383592 creator A5028280438 @default.
- W4313383592 creator A5037887288 @default.
- W4313383592 creator A5051060828 @default.
- W4313383592 creator A5070495231 @default.
- W4313383592 date "2018-05-01" @default.
- W4313383592 modified "2023-09-27" @default.
- W4313383592 title "Dampening the B Cell Response, a modified lipid story." @default.
- W4313383592 doi "https://doi.org/10.4049/jimmunol.200.supp.107.15" @default.
- W4313383592 hasPublicationYear "2018" @default.
- W4313383592 type Work @default.
- W4313383592 citedByCount "0" @default.
- W4313383592 crossrefType "journal-article" @default.
- W4313383592 hasAuthorship W4313383592A5000483511 @default.
- W4313383592 hasAuthorship W4313383592A5004568835 @default.
- W4313383592 hasAuthorship W4313383592A5028280438 @default.
- W4313383592 hasAuthorship W4313383592A5037887288 @default.
- W4313383592 hasAuthorship W4313383592A5051060828 @default.
- W4313383592 hasAuthorship W4313383592A5070495231 @default.
- W4313383592 hasConcept C104317684 @default.
- W4313383592 hasConcept C108636557 @default.
- W4313383592 hasConcept C127561419 @default.
- W4313383592 hasConcept C150903083 @default.
- W4313383592 hasConcept C154317977 @default.
- W4313383592 hasConcept C157695867 @default.
- W4313383592 hasConcept C159654299 @default.
- W4313383592 hasConcept C164027704 @default.
- W4313383592 hasConcept C175818844 @default.
- W4313383592 hasConcept C185592680 @default.
- W4313383592 hasConcept C202751555 @default.
- W4313383592 hasConcept C203014093 @default.
- W4313383592 hasConcept C207001950 @default.
- W4313383592 hasConcept C2776914184 @default.
- W4313383592 hasConcept C2777730290 @default.
- W4313383592 hasConcept C2777895019 @default.
- W4313383592 hasConcept C2778453870 @default.
- W4313383592 hasConcept C2779244956 @default.
- W4313383592 hasConcept C2779730028 @default.
- W4313383592 hasConcept C35174551 @default.
- W4313383592 hasConcept C39347974 @default.
- W4313383592 hasConcept C42362537 @default.
- W4313383592 hasConcept C55493867 @default.
- W4313383592 hasConcept C62478195 @default.
- W4313383592 hasConcept C86803240 @default.
- W4313383592 hasConcept C8891405 @default.
- W4313383592 hasConcept C90059517 @default.
- W4313383592 hasConcept C95444343 @default.
- W4313383592 hasConceptScore W4313383592C104317684 @default.
- W4313383592 hasConceptScore W4313383592C108636557 @default.
- W4313383592 hasConceptScore W4313383592C127561419 @default.
- W4313383592 hasConceptScore W4313383592C150903083 @default.
- W4313383592 hasConceptScore W4313383592C154317977 @default.
- W4313383592 hasConceptScore W4313383592C157695867 @default.
- W4313383592 hasConceptScore W4313383592C159654299 @default.
- W4313383592 hasConceptScore W4313383592C164027704 @default.
- W4313383592 hasConceptScore W4313383592C175818844 @default.
- W4313383592 hasConceptScore W4313383592C185592680 @default.
- W4313383592 hasConceptScore W4313383592C202751555 @default.
- W4313383592 hasConceptScore W4313383592C203014093 @default.
- W4313383592 hasConceptScore W4313383592C207001950 @default.
- W4313383592 hasConceptScore W4313383592C2776914184 @default.
- W4313383592 hasConceptScore W4313383592C2777730290 @default.
- W4313383592 hasConceptScore W4313383592C2777895019 @default.
- W4313383592 hasConceptScore W4313383592C2778453870 @default.
- W4313383592 hasConceptScore W4313383592C2779244956 @default.
- W4313383592 hasConceptScore W4313383592C2779730028 @default.
- W4313383592 hasConceptScore W4313383592C35174551 @default.
- W4313383592 hasConceptScore W4313383592C39347974 @default.
- W4313383592 hasConceptScore W4313383592C42362537 @default.
- W4313383592 hasConceptScore W4313383592C55493867 @default.
- W4313383592 hasConceptScore W4313383592C62478195 @default.
- W4313383592 hasConceptScore W4313383592C86803240 @default.
- W4313383592 hasConceptScore W4313383592C8891405 @default.
- W4313383592 hasConceptScore W4313383592C90059517 @default.
- W4313383592 hasConceptScore W4313383592C95444343 @default.
- W4313383592 hasIssue "1_Supplement" @default.
- W4313383592 hasLocation W43133835921 @default.
- W4313383592 hasOpenAccess W4313383592 @default.
- W4313383592 hasPrimaryLocation W43133835921 @default.
- W4313383592 hasRelatedWork W1516604621 @default.
- W4313383592 hasRelatedWork W1982411778 @default.
- W4313383592 hasRelatedWork W2166706442 @default.
- W4313383592 hasRelatedWork W2600719372 @default.
- W4313383592 hasRelatedWork W2601929339 @default.
- W4313383592 hasRelatedWork W2923806832 @default.
- W4313383592 hasRelatedWork W4253106962 @default.
- W4313383592 hasRelatedWork W4313383592 @default.
- W4313383592 hasRelatedWork W82236224 @default.
- W4313383592 hasRelatedWork W925124261 @default.
- W4313383592 hasVolume "200" @default.
- W4313383592 isParatext "false" @default.
- W4313383592 isRetracted "false" @default.
- W4313383592 workType "article" @default.