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- W4313383602 startingPage "99.29" @default.
- W4313383602 abstract "Abstract Antigen persistence following viral infection or vaccination occurs for several weeks after resolution of the inflammatory response. Lymphatic endothelial cells (LECs) capture and archive antigen, which is then transferred to migratory dendritic cells (DCs) and ultimately cross-presented to circulating memory T cells. Following vaccination, both BatF3-dependent and BatF3-independent DCs are needed for antigen exchange, while virus-associated antigen exchange is mediated only by BatF3-dependent DCs. Here, we explore the role of apoptotic and scavenger receptors in mediating this antigen capture and exchange between LECs and DCs. Cross-presentation of the DC-associated antigen to circulating T cells results in a memory pool with increased effector function and enhanced protective capacity. Overall, this work furthers our understanding of how persisting antigen impacts the CD8+ memory T cell response in both vaccine and infectious settings." @default.
- W4313383602 created "2023-01-06" @default.
- W4313383602 creator A5004079262 @default.
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- W4313383602 date "2018-05-01" @default.
- W4313383602 modified "2023-10-15" @default.
- W4313383602 title "A role for apoptotic and scavenger receptors in mediating antigen exchange between lymphatic endothelial cells and migratory dendritic cells" @default.
- W4313383602 doi "https://doi.org/10.4049/jimmunol.200.supp.99.29" @default.
- W4313383602 hasPublicationYear "2018" @default.
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