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- W4313383708 abstract "Abstract CD4+Foxp3+ regulatory T cells (Tregs) are key players in preventing lethal autoimmunity and excessive inflammation. However, the homeostatic dynamics of Tregs in peripheral lymphoid and non-lymphoid tissues remains poorly defined. We here report that two TCF/LEF family transcription factors, LEF1 and TCF1, play critical roles in this process. Our studies led to a revised “three-stage” model of Treg peripheral differentiation, delineated by the gradient expressions of LEF1 and TCF1. We found that LEF1− TCF1− subset was bona fide effector Tregs and exhibited a core gene signature shared by various tissue Tregs. Transcriptome and conditional knockout analyses revealed that TCF1 and LEF1 may each control segregated clusters of Treg genes and regulate Treg differentiation in a “division of labor” manner. Together, these data provide novel insights into transcriptional regulation of Treg homeostasis and function." @default.
- W4313383708 created "2023-01-06" @default.
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- W4313383708 date "2018-05-01" @default.
- W4313383708 modified "2023-09-27" @default.
- W4313383708 title "TCF/LEF family transcription factors in peripheral Treg homeostasis" @default.
- W4313383708 doi "https://doi.org/10.4049/jimmunol.200.supp.116.11" @default.
- W4313383708 hasPublicationYear "2018" @default.
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