Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383741> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313383741 endingPage "178.17" @default.
- W4313383741 startingPage "178.17" @default.
- W4313383741 abstract "Abstract Cancer cell lines grown in vitro and implanted into mice are a centerpiece of preclinical modeling. However, tumor implantation is an in vivo vaccination event that can impact tumor growth. Checkpoint inhibitors targeting PD1 or CTLA4 interactions are effective at unleashing suppressed pre-existing immunity in murine models, but do not generate new immune responses. We hypothesized that tumor control by checkpoint inhibitor immunotherapies was dependent on pre-existing immunity generated at tumor implantation. Using cancer cells engineered to express model antigens, spontaneous tumor models with defined trackable antigens, or unmodified cancer cells, we demonstrate that tumor implantation results in initial T cell mediated immunity. As the tumors progress, these cells become undetectable in the periphery and accumulate in the tumor, but do not prevent tumor progression. While tumors respond to checkpoint inhibitors administered closely following implantation, delayed administration results in a loss of efficacy. This efficacy can be recovered by the addition of radiation therapy to checkpoint inhibitors, permitting cure of established murine tumors that are not controlled by either therapy alone. However, blocking the immune response at tumor implantation using a range of approaches results in a complete loss of efficacy of tumor control by all therapies based around checkpoint inhibitors. We demonstrate an approach to ‘silently’ establish tumors in mice to test therapies that can initiate de novo immunity to tumors. These data have significant implications for current clinical attempts to use checkpoint inhibitors, which may not be a solution for patients without pre-existing immunity to their tumor." @default.
- W4313383741 created "2023-01-06" @default.
- W4313383741 creator A5001858951 @default.
- W4313383741 creator A5006131701 @default.
- W4313383741 creator A5014869775 @default.
- W4313383741 creator A5017245866 @default.
- W4313383741 creator A5023455309 @default.
- W4313383741 creator A5024523886 @default.
- W4313383741 creator A5034752370 @default.
- W4313383741 creator A5051320936 @default.
- W4313383741 creator A5069363745 @default.
- W4313383741 creator A5081601892 @default.
- W4313383741 date "2018-05-01" @default.
- W4313383741 modified "2023-09-23" @default.
- W4313383741 title "Anti-tumor immunity generated as an artifact of tumor implantation determines the response to immunotherapy in murine models" @default.
- W4313383741 doi "https://doi.org/10.4049/jimmunol.200.supp.178.17" @default.
- W4313383741 hasPublicationYear "2018" @default.
- W4313383741 type Work @default.
- W4313383741 citedByCount "0" @default.
- W4313383741 crossrefType "journal-article" @default.
- W4313383741 hasAuthorship W4313383741A5001858951 @default.
- W4313383741 hasAuthorship W4313383741A5006131701 @default.
- W4313383741 hasAuthorship W4313383741A5014869775 @default.
- W4313383741 hasAuthorship W4313383741A5017245866 @default.
- W4313383741 hasAuthorship W4313383741A5023455309 @default.
- W4313383741 hasAuthorship W4313383741A5024523886 @default.
- W4313383741 hasAuthorship W4313383741A5034752370 @default.
- W4313383741 hasAuthorship W4313383741A5051320936 @default.
- W4313383741 hasAuthorship W4313383741A5069363745 @default.
- W4313383741 hasAuthorship W4313383741A5081601892 @default.
- W4313383741 hasConcept C121608353 @default.
- W4313383741 hasConcept C126322002 @default.
- W4313383741 hasConcept C147483822 @default.
- W4313383741 hasConcept C150903083 @default.
- W4313383741 hasConcept C203014093 @default.
- W4313383741 hasConcept C207001950 @default.
- W4313383741 hasConcept C2777701055 @default.
- W4313383741 hasConcept C2779341262 @default.
- W4313383741 hasConcept C2780674031 @default.
- W4313383741 hasConcept C2780851360 @default.
- W4313383741 hasConcept C502942594 @default.
- W4313383741 hasConcept C71924100 @default.
- W4313383741 hasConcept C86803240 @default.
- W4313383741 hasConcept C8891405 @default.
- W4313383741 hasConceptScore W4313383741C121608353 @default.
- W4313383741 hasConceptScore W4313383741C126322002 @default.
- W4313383741 hasConceptScore W4313383741C147483822 @default.
- W4313383741 hasConceptScore W4313383741C150903083 @default.
- W4313383741 hasConceptScore W4313383741C203014093 @default.
- W4313383741 hasConceptScore W4313383741C207001950 @default.
- W4313383741 hasConceptScore W4313383741C2777701055 @default.
- W4313383741 hasConceptScore W4313383741C2779341262 @default.
- W4313383741 hasConceptScore W4313383741C2780674031 @default.
- W4313383741 hasConceptScore W4313383741C2780851360 @default.
- W4313383741 hasConceptScore W4313383741C502942594 @default.
- W4313383741 hasConceptScore W4313383741C71924100 @default.
- W4313383741 hasConceptScore W4313383741C86803240 @default.
- W4313383741 hasConceptScore W4313383741C8891405 @default.
- W4313383741 hasIssue "1_Supplement" @default.
- W4313383741 hasLocation W43133837411 @default.
- W4313383741 hasOpenAccess W4313383741 @default.
- W4313383741 hasPrimaryLocation W43133837411 @default.
- W4313383741 hasRelatedWork W1183554201 @default.
- W4313383741 hasRelatedWork W2763883091 @default.
- W4313383741 hasRelatedWork W2765869937 @default.
- W4313383741 hasRelatedWork W2886039816 @default.
- W4313383741 hasRelatedWork W3000019484 @default.
- W4313383741 hasRelatedWork W3180780036 @default.
- W4313383741 hasRelatedWork W3217412908 @default.
- W4313383741 hasRelatedWork W4291367166 @default.
- W4313383741 hasRelatedWork W4294940896 @default.
- W4313383741 hasRelatedWork W4311194870 @default.
- W4313383741 hasVolume "200" @default.
- W4313383741 isParatext "false" @default.
- W4313383741 isRetracted "false" @default.
- W4313383741 workType "article" @default.