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- W4313383867 abstract "Abstract Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages co-circulate worldwide with limited antigenic cross-reactivity between each other. Licensed seasonal influenza vaccines are available as inactivated, recombinant, or live attenuated influenza virus (LAIV) vaccines. Although LAIV vaccines mimic a natural infection that is thought to provide better cross-protection than inactivated vaccines, the former are not currently recommended by the CDC for use in the US due to the sub-optimal efficacy. In order to improve LAIV vaccines and following the footsteps of similar work performed by our laboratory using influenza A viruses, we sought to develop an IBV LAIV vaccine. Thus, we created an IBV LAIV using a two-strategy combination that incorporates temperature sensitive (ts) mutations and an epitope tag in the PB1 gene segment. Such modifications resulted in a LAIV candidate with ts characteristics in vitro. We assessed vaccine safety following intranasal immunization and found that IBV LAIV displayed an attenuated (att) phenotype in vivo with virus replication restricted to the upper respiratory tract. Immunization experiments further showed that a single dose of IBV LAIV candidate conferred sterilizing immunity against lethal homologous challenge. Single immunization with IBV LAIV also provided complete protection against heterologous challenge as evidenced by reduced weight loss and lung viral titers. The ability of LAIV to induce cross-protective immune responses may have important implications for the development of universal influenza vaccine approaches." @default.
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- W4313383867 date "2018-05-01" @default.
- W4313383867 modified "2023-10-18" @default.
- W4313383867 title "Homologous and heterologous protection against influenza B virus following live attenuated influenza virus (LAIV) immunization" @default.
- W4313383867 doi "https://doi.org/10.4049/jimmunol.200.supp.180.16" @default.
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