Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383885> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313383885 endingPage "40.9" @default.
- W4313383885 startingPage "40.9" @default.
- W4313383885 abstract "Abstract CD8 T cell function, unlike CD4 T cells, in antibody-mediated autoimmune disease remains largely unexplored. CD8 T cells act as either cytotoxic or helper-like cells during autoimmunity. CD4 T follicular cells (Tfh) interact with B cells to promote proliferation, activation and antibody class switching. CXCR5+PD-1hi CD8 T follicular (Tfc) cells localized within the germinal center resemble CD4 Tfh cells in multiple models of spontaneous autoantibody-mediated disease, including IL-2 deficient (IL-2-KO), Scurfy and MRL/MpJ-FASlprmice. CD4 and CD8 T cells activated with NP-KLH synergistically induce B cell class switching to IgG1 IgG2a, IgG2b, and IgG3 in vivo. RNA-sequencing of IL-2-KO CD8 Tfc and IL-2-KO CD4 Tfh cells identified 478 differentially expressed genes unique to CD8 Tfc cells. These data revealed an increased expression of genes associated with CD8 Tfc cell function including il21, ifnγ, prf1. IL-21 produced by CD4 Tfh cells but not CD8 Tfc cells promotes total IgG class switching demonstrated by in vitro cultures of activated autoimmune CD8 Tfc or CD4 Tfh cell supernatant incubated with IL-21R-KO B cells. IFNγ x IL-2-KO mice develop both CD4 Tfh and CD8 Tfc cells correlating with autoantibody production. In vitro culture assays demonstrate that IFNγ produced by CD8 Tfc cells promotes B cell class switching to. Our results indicate that CD8 Tfc cells contribute to autoimmune disease synergistically with CD4 Tfh cells to induce B cell differentiation and antibody class-switch. We are continuing to explore the unique functions of CD8 Tfc cells on germinal center interactions." @default.
- W4313383885 created "2023-01-06" @default.
- W4313383885 creator A5001268761 @default.
- W4313383885 creator A5030348929 @default.
- W4313383885 creator A5043291953 @default.
- W4313383885 creator A5083934299 @default.
- W4313383885 date "2018-05-01" @default.
- W4313383885 modified "2023-09-27" @default.
- W4313383885 title "Follicular CD8 T cells function in germinal center reactions to promote autoantibody-mediated disease." @default.
- W4313383885 doi "https://doi.org/10.4049/jimmunol.200.supp.40.9" @default.
- W4313383885 hasPublicationYear "2018" @default.
- W4313383885 type Work @default.
- W4313383885 citedByCount "0" @default.
- W4313383885 crossrefType "journal-article" @default.
- W4313383885 hasAuthorship W4313383885A5001268761 @default.
- W4313383885 hasAuthorship W4313383885A5030348929 @default.
- W4313383885 hasAuthorship W4313383885A5043291953 @default.
- W4313383885 hasAuthorship W4313383885A5083934299 @default.
- W4313383885 hasConcept C129374314 @default.
- W4313383885 hasConcept C137756551 @default.
- W4313383885 hasConcept C153911025 @default.
- W4313383885 hasConcept C154317977 @default.
- W4313383885 hasConcept C159654299 @default.
- W4313383885 hasConcept C167672396 @default.
- W4313383885 hasConcept C202751555 @default.
- W4313383885 hasConcept C203014093 @default.
- W4313383885 hasConcept C2776090121 @default.
- W4313383885 hasConcept C2776708503 @default.
- W4313383885 hasConcept C2778453870 @default.
- W4313383885 hasConcept C55493867 @default.
- W4313383885 hasConcept C86803240 @default.
- W4313383885 hasConcept C8891405 @default.
- W4313383885 hasConcept C95444343 @default.
- W4313383885 hasConcept C96926380 @default.
- W4313383885 hasConceptScore W4313383885C129374314 @default.
- W4313383885 hasConceptScore W4313383885C137756551 @default.
- W4313383885 hasConceptScore W4313383885C153911025 @default.
- W4313383885 hasConceptScore W4313383885C154317977 @default.
- W4313383885 hasConceptScore W4313383885C159654299 @default.
- W4313383885 hasConceptScore W4313383885C167672396 @default.
- W4313383885 hasConceptScore W4313383885C202751555 @default.
- W4313383885 hasConceptScore W4313383885C203014093 @default.
- W4313383885 hasConceptScore W4313383885C2776090121 @default.
- W4313383885 hasConceptScore W4313383885C2776708503 @default.
- W4313383885 hasConceptScore W4313383885C2778453870 @default.
- W4313383885 hasConceptScore W4313383885C55493867 @default.
- W4313383885 hasConceptScore W4313383885C86803240 @default.
- W4313383885 hasConceptScore W4313383885C8891405 @default.
- W4313383885 hasConceptScore W4313383885C95444343 @default.
- W4313383885 hasConceptScore W4313383885C96926380 @default.
- W4313383885 hasIssue "1_Supplement" @default.
- W4313383885 hasLocation W43133838851 @default.
- W4313383885 hasOpenAccess W4313383885 @default.
- W4313383885 hasPrimaryLocation W43133838851 @default.
- W4313383885 hasRelatedWork W1609716101 @default.
- W4313383885 hasRelatedWork W1929236283 @default.
- W4313383885 hasRelatedWork W1989888511 @default.
- W4313383885 hasRelatedWork W2169310943 @default.
- W4313383885 hasRelatedWork W2501034558 @default.
- W4313383885 hasRelatedWork W2613523734 @default.
- W4313383885 hasRelatedWork W2921028124 @default.
- W4313383885 hasRelatedWork W4313359277 @default.
- W4313383885 hasRelatedWork W4313383885 @default.
- W4313383885 hasRelatedWork W88926344 @default.
- W4313383885 hasVolume "200" @default.
- W4313383885 isParatext "false" @default.
- W4313383885 isRetracted "false" @default.
- W4313383885 workType "article" @default.