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- W4313383951 abstract "Abstract The mammalian immune system has evolved both effector and regulatory immune axes, and T cells are the key players in both arms. The immune system sorts, responds to and clears invading pathogens through pro-inflammatory activity, which can cause damage to the affected tissues, and eventually have to be resolved to allow tissue remodeling and resume physiological homeostasis. The balance between pro-inflammatory and suppressive immune functions are critical for host health and survival. The T cell antigen receptor (TCR) signals through the downstream non-receptor interleukin-2 inducible T cell kinase (ITK), which is a key signaling modulator of T cell development, differentiation, activation and function. We find that in the face of different inflammatory and nutritional conditions, the TCR/ITK signaling pathway fine-tunes the balance between effector and regulatory T cell development, such as the ratio between Th17/Treg and Th1/Tr1 cells. This balance is regulated by the TCR/ITK signaling via differential downstream signals and metabolic programs. While ITK is not required for T cell activation, it functions as a rheostat of the TCR to regulate signal strength in response to extracellular antigens, and may be a target to allow therapeutically manipulating the balance between effector and regulatory immunity, dependent on the disease conditions." @default.
- W4313383951 created "2023-01-06" @default.
- W4313383951 creator A5000896541 @default.
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- W4313383951 date "2018-05-01" @default.
- W4313383951 modified "2023-09-25" @default.
- W4313383951 title "The TCR/ITK signaling pathway regulates the counterbalance of effector and regulatory T cell development" @default.
- W4313383951 doi "https://doi.org/10.4049/jimmunol.200.supp.116.14" @default.
- W4313383951 hasPublicationYear "2018" @default.
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