Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313383959> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313383959 endingPage "171.21" @default.
- W4313383959 startingPage "171.21" @default.
- W4313383959 abstract "Abstract T helper 17 (Th17) cells are one of CD4+ T cell subsets that mediate inflammation and autoimmunity. Unlike other subsets, interleukin 2 (IL-2) inhibits differentiation of Th17 cells but the mechanism that regulates Th17 differentiation is poorly understood. Here, we show that phosphatase and tensin homologue (PTEN) plays key role in Th17 cell differentiation by regulating IL-2 expression. We generated Th17-specific Pten knock-out mice (Pten fl/fl Il17a CRE) to investigate intrinsic role of PTEN. Th17-specific Pten deletion inhibited Th17 differentiation by inducing excessive expression of IL-2 in vitro. Over-expressed IL-2 recognized by IL-2 receptor and induced phosphorylation of STAT5, eventually triggered Foxp3 expression in Th17 cells. Next, we used experimental autoimmune encephalomyelitis (EAE) as in vivo model, Th17-specific deficiency of Pten ameliorated symptoms of EAE. Additionally, we used SF1670 which is PTEN-specific inhibitor for therapeutic approach. Treatment of SF1670 to EAE induced mice showed ameliorated symptoms of EAE, therefore PTEN may be a potential therapeutic target for Th17-mediated diseases." @default.
- W4313383959 created "2023-01-06" @default.
- W4313383959 creator A5009407745 @default.
- W4313383959 creator A5044483735 @default.
- W4313383959 creator A5075274633 @default.
- W4313383959 date "2018-05-01" @default.
- W4313383959 modified "2023-09-26" @default.
- W4313383959 title "Phosphatase PTEN-mediated blockade of IL-2 production is essential for Th17 cell differentiation" @default.
- W4313383959 doi "https://doi.org/10.4049/jimmunol.200.supp.171.21" @default.
- W4313383959 hasPublicationYear "2018" @default.
- W4313383959 type Work @default.
- W4313383959 citedByCount "0" @default.
- W4313383959 crossrefType "journal-article" @default.
- W4313383959 hasAuthorship W4313383959A5009407745 @default.
- W4313383959 hasAuthorship W4313383959A5044483735 @default.
- W4313383959 hasAuthorship W4313383959A5075274633 @default.
- W4313383959 hasConcept C11960822 @default.
- W4313383959 hasConcept C178666793 @default.
- W4313383959 hasConcept C185592680 @default.
- W4313383959 hasConcept C203014093 @default.
- W4313383959 hasConcept C2776090121 @default.
- W4313383959 hasConcept C2776914184 @default.
- W4313383959 hasConcept C2777609662 @default.
- W4313383959 hasConcept C2778486448 @default.
- W4313383959 hasConcept C2779549131 @default.
- W4313383959 hasConcept C2779727006 @default.
- W4313383959 hasConcept C2780130043 @default.
- W4313383959 hasConcept C47348012 @default.
- W4313383959 hasConcept C502942594 @default.
- W4313383959 hasConcept C62478195 @default.
- W4313383959 hasConcept C86554907 @default.
- W4313383959 hasConcept C86803240 @default.
- W4313383959 hasConcept C8891405 @default.
- W4313383959 hasConcept C95444343 @default.
- W4313383959 hasConceptScore W4313383959C11960822 @default.
- W4313383959 hasConceptScore W4313383959C178666793 @default.
- W4313383959 hasConceptScore W4313383959C185592680 @default.
- W4313383959 hasConceptScore W4313383959C203014093 @default.
- W4313383959 hasConceptScore W4313383959C2776090121 @default.
- W4313383959 hasConceptScore W4313383959C2776914184 @default.
- W4313383959 hasConceptScore W4313383959C2777609662 @default.
- W4313383959 hasConceptScore W4313383959C2778486448 @default.
- W4313383959 hasConceptScore W4313383959C2779549131 @default.
- W4313383959 hasConceptScore W4313383959C2779727006 @default.
- W4313383959 hasConceptScore W4313383959C2780130043 @default.
- W4313383959 hasConceptScore W4313383959C47348012 @default.
- W4313383959 hasConceptScore W4313383959C502942594 @default.
- W4313383959 hasConceptScore W4313383959C62478195 @default.
- W4313383959 hasConceptScore W4313383959C86554907 @default.
- W4313383959 hasConceptScore W4313383959C86803240 @default.
- W4313383959 hasConceptScore W4313383959C8891405 @default.
- W4313383959 hasConceptScore W4313383959C95444343 @default.
- W4313383959 hasIssue "1_Supplement" @default.
- W4313383959 hasLocation W43133839591 @default.
- W4313383959 hasOpenAccess W4313383959 @default.
- W4313383959 hasPrimaryLocation W43133839591 @default.
- W4313383959 hasRelatedWork W1857859338 @default.
- W4313383959 hasRelatedWork W2167243939 @default.
- W4313383959 hasRelatedWork W2197904459 @default.
- W4313383959 hasRelatedWork W2219191688 @default.
- W4313383959 hasRelatedWork W2744966301 @default.
- W4313383959 hasRelatedWork W2900464141 @default.
- W4313383959 hasRelatedWork W4289705004 @default.
- W4313383959 hasRelatedWork W4313383959 @default.
- W4313383959 hasRelatedWork W4319242539 @default.
- W4313383959 hasRelatedWork W2522379078 @default.
- W4313383959 hasVolume "200" @default.
- W4313383959 isParatext "false" @default.
- W4313383959 isRetracted "false" @default.
- W4313383959 workType "article" @default.