Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313384002> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313384002 endingPage "56.24" @default.
- W4313384002 startingPage "56.24" @default.
- W4313384002 abstract "Abstract Cell-cell fusion is a common biological phenomenon involved in both healthy and disease conditions. Fusion occurs when two or more cells combine their plasma membranes and become a single hybrid cell that retains certain genetic information from each parent cell. Here, using a Cre-loxP-based method initially developed to investigate extracellular vesicle targeting, we found that cancer cells spontaneously and rapidly deliver DNA to non-cancer cells in vitro via a cell-cell fusion event. We found that B16 melanoma cells and progressor and regressor fibrosarcomas were capable of spontaneously fusing with immune cells (macrophages) and non-immune cells (fibroblasts) in vitro, with varying degrees of efficiency. Further analysis of hybrid clones resulting from fusion between B16 melanoma cells and mouse embryonic fibroblasts showed that these cells were aneuploid and possessed enhanced clonal diversity and chemoresistance compared to non-hybrid melanoma cells. We also observed cell-cell fusion to occur in vivo between melanoma cells and non-cancer cells of both hematopoietic and non-hematopoietic origin. These findings suggest that cell-cell fusion occurs in murine cancer models and show that this mechanism has the potential to cause massive genomic alterations that are observed in cancer. Furthermore, these findings somewhat contradict recent publications suggesting that the Cre-loxP method measures only extracellular vesicle-mediated intercellular communication." @default.
- W4313384002 created "2023-01-06" @default.
- W4313384002 creator A5021197605 @default.
- W4313384002 creator A5076142846 @default.
- W4313384002 creator A5079751653 @default.
- W4313384002 date "2018-05-01" @default.
- W4313384002 modified "2023-09-27" @default.
- W4313384002 title "Cell-cell fusion as a mechanism of DNA exchange in cancer" @default.
- W4313384002 doi "https://doi.org/10.4049/jimmunol.200.supp.56.24" @default.
- W4313384002 hasPublicationYear "2018" @default.
- W4313384002 type Work @default.
- W4313384002 citedByCount "0" @default.
- W4313384002 crossrefType "journal-article" @default.
- W4313384002 hasAuthorship W4313384002A5021197605 @default.
- W4313384002 hasAuthorship W4313384002A5076142846 @default.
- W4313384002 hasAuthorship W4313384002A5079751653 @default.
- W4313384002 hasConcept C104317684 @default.
- W4313384002 hasConcept C121608353 @default.
- W4313384002 hasConcept C145103041 @default.
- W4313384002 hasConcept C1491633281 @default.
- W4313384002 hasConcept C203014093 @default.
- W4313384002 hasConcept C502942594 @default.
- W4313384002 hasConcept C54355233 @default.
- W4313384002 hasConcept C86803240 @default.
- W4313384002 hasConcept C8891405 @default.
- W4313384002 hasConcept C92488253 @default.
- W4313384002 hasConcept C95444343 @default.
- W4313384002 hasConcept C96232424 @default.
- W4313384002 hasConceptScore W4313384002C104317684 @default.
- W4313384002 hasConceptScore W4313384002C121608353 @default.
- W4313384002 hasConceptScore W4313384002C145103041 @default.
- W4313384002 hasConceptScore W4313384002C1491633281 @default.
- W4313384002 hasConceptScore W4313384002C203014093 @default.
- W4313384002 hasConceptScore W4313384002C502942594 @default.
- W4313384002 hasConceptScore W4313384002C54355233 @default.
- W4313384002 hasConceptScore W4313384002C86803240 @default.
- W4313384002 hasConceptScore W4313384002C8891405 @default.
- W4313384002 hasConceptScore W4313384002C92488253 @default.
- W4313384002 hasConceptScore W4313384002C95444343 @default.
- W4313384002 hasConceptScore W4313384002C96232424 @default.
- W4313384002 hasIssue "1_Supplement" @default.
- W4313384002 hasLocation W43133840021 @default.
- W4313384002 hasOpenAccess W4313384002 @default.
- W4313384002 hasPrimaryLocation W43133840021 @default.
- W4313384002 hasRelatedWork W1567838078 @default.
- W4313384002 hasRelatedWork W2064570455 @default.
- W4313384002 hasRelatedWork W2339808165 @default.
- W4313384002 hasRelatedWork W2344637265 @default.
- W4313384002 hasRelatedWork W2974647127 @default.
- W4313384002 hasRelatedWork W3189892794 @default.
- W4313384002 hasRelatedWork W3215939181 @default.
- W4313384002 hasRelatedWork W4283731173 @default.
- W4313384002 hasRelatedWork W4291367166 @default.
- W4313384002 hasRelatedWork W4308359949 @default.
- W4313384002 hasVolume "200" @default.
- W4313384002 isParatext "false" @default.
- W4313384002 isRetracted "false" @default.
- W4313384002 workType "article" @default.