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- W4313384004 abstract "Abstract Self-tolerance removes or inactivates autoreactive B cells in primary and secondary lymphoid organs. Studies have used transgenic mouse models or characterizing recombinant antibodies from single B cells to study B-cell tolerance. These approaches are limited, however, by the restricted diversity of transgenic B-cell repertoires or the effort necessary to generate significant numbers of recombinant antibodies. To overcome these difficulties, we used a single-cell culture approach, which supports high-throughput analysis of the B-cell repertoire in pre-tolerance, post-tolerance, and tolerizing anergic B-cell compartments. This approach revealed the affinity “setpoints” of the tolerance checkpoints, the stochastic nature of B-cell tolerance, and subsets of autoreactive B cells that are persistent in periphery. We propose that these anergic compartments may be the origin of systemic autoimmunity and a potential target for HIV-1 vaccines that elicit neutralizing antibodies cross-reactive with self-antigens." @default.
- W4313384004 created "2023-01-06" @default.
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- W4313384004 date "2018-05-01" @default.
- W4313384004 modified "2023-09-27" @default.
- W4313384004 title "Tracing self-reactive B cells in normal mice" @default.
- W4313384004 doi "https://doi.org/10.4049/jimmunol.200.supp.40.13" @default.
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