Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313384229> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313384229 endingPage "56.7" @default.
- W4313384229 startingPage "56.7" @default.
- W4313384229 abstract "Abstract Epidemiological studies suggest diets enriched with soy confer a lower risk of prostate cancer. Data from our group and others indicate that soy has immunomodulatory properties which may contribute to their health promoting effects. Prior results from our group in a randomized phase II clinical trial revealed that men with asymptomatic prostate cancer on a soy-enriched diet had significantly reduced systemic inflammatory cytokines and myeloid-derived suppressor cells (MDSCs). We hypothesized that a soy-enriched diet limits systemic immunosuppression by reducing MDSC expansion. To understand how dietary soy modulates immune biomarkers in prostate cancer, we administered TRAMP (transgenic adenocarcinoma of the mouse prostate) mice a soy-enriched (n=28) or control diet (n=32) for 16 weeks. TRAMP mice administered a soy-enriched diet had a reduced tumor burden compared to control fed mice (p=0.0419). Splenic CD11b+Ly6GloLy6C− granulocytic (p=0.0195), CD11b+Ly6C+Ly6G− monocytic (p=0.0005), and total MDSCs (p=0.0009) were significantly reduced in TRAMP mice on a soy-enriched diet compared to control diet. However, we did not observe differences in circulating CD4+CD25+Foxp3+ T-regulatory cells or other circulating immune subsets such as CD4+ T cells, phenotypically defined T helper-1 (CD4+CXCR3+CCR4−CCR6−)/T helper-2 (CD4+CCR4+CXCR3+CCR6−) T cells, CD8+ T cells, and NK cells. Ongoing studies are examining plasma cytokine levels and immunosuppressive cell populations in the tumor microenvironment of mice from this study. Together, these data indicate that soy as a dietary natural product may have a modulatory effect during chemopreventive or immunotherapy in the setting of prostate cancer." @default.
- W4313384229 created "2023-01-06" @default.
- W4313384229 creator A5000521206 @default.
- W4313384229 creator A5013392249 @default.
- W4313384229 creator A5014062413 @default.
- W4313384229 creator A5024548257 @default.
- W4313384229 creator A5025535317 @default.
- W4313384229 creator A5030704876 @default.
- W4313384229 creator A5032094154 @default.
- W4313384229 creator A5055818741 @default.
- W4313384229 creator A5067139092 @default.
- W4313384229 creator A5071526001 @default.
- W4313384229 creator A5083704243 @default.
- W4313384229 date "2018-05-01" @default.
- W4313384229 modified "2023-09-27" @default.
- W4313384229 title "Soy-enriched diet limits tumor progression and reduces myeloid derived suppressor cells in the murine TRAMP model of prostate cancer." @default.
- W4313384229 doi "https://doi.org/10.4049/jimmunol.200.supp.56.7" @default.
- W4313384229 hasPublicationYear "2018" @default.
- W4313384229 type Work @default.
- W4313384229 citedByCount "0" @default.
- W4313384229 crossrefType "journal-article" @default.
- W4313384229 hasAuthorship W4313384229A5000521206 @default.
- W4313384229 hasAuthorship W4313384229A5013392249 @default.
- W4313384229 hasAuthorship W4313384229A5014062413 @default.
- W4313384229 hasAuthorship W4313384229A5024548257 @default.
- W4313384229 hasAuthorship W4313384229A5025535317 @default.
- W4313384229 hasAuthorship W4313384229A5030704876 @default.
- W4313384229 hasAuthorship W4313384229A5032094154 @default.
- W4313384229 hasAuthorship W4313384229A5055818741 @default.
- W4313384229 hasAuthorship W4313384229A5067139092 @default.
- W4313384229 hasAuthorship W4313384229A5071526001 @default.
- W4313384229 hasAuthorship W4313384229A5083704243 @default.
- W4313384229 hasConcept C121608353 @default.
- W4313384229 hasConcept C126322002 @default.
- W4313384229 hasConcept C134018914 @default.
- W4313384229 hasConcept C167672396 @default.
- W4313384229 hasConcept C179185449 @default.
- W4313384229 hasConcept C203014093 @default.
- W4313384229 hasConcept C2776090121 @default.
- W4313384229 hasConcept C2779727006 @default.
- W4313384229 hasConcept C2780192828 @default.
- W4313384229 hasConcept C2780940892 @default.
- W4313384229 hasConcept C502942594 @default.
- W4313384229 hasConcept C55721878 @default.
- W4313384229 hasConcept C71924100 @default.
- W4313384229 hasConcept C79484868 @default.
- W4313384229 hasConcept C8891405 @default.
- W4313384229 hasConceptScore W4313384229C121608353 @default.
- W4313384229 hasConceptScore W4313384229C126322002 @default.
- W4313384229 hasConceptScore W4313384229C134018914 @default.
- W4313384229 hasConceptScore W4313384229C167672396 @default.
- W4313384229 hasConceptScore W4313384229C179185449 @default.
- W4313384229 hasConceptScore W4313384229C203014093 @default.
- W4313384229 hasConceptScore W4313384229C2776090121 @default.
- W4313384229 hasConceptScore W4313384229C2779727006 @default.
- W4313384229 hasConceptScore W4313384229C2780192828 @default.
- W4313384229 hasConceptScore W4313384229C2780940892 @default.
- W4313384229 hasConceptScore W4313384229C502942594 @default.
- W4313384229 hasConceptScore W4313384229C55721878 @default.
- W4313384229 hasConceptScore W4313384229C71924100 @default.
- W4313384229 hasConceptScore W4313384229C79484868 @default.
- W4313384229 hasConceptScore W4313384229C8891405 @default.
- W4313384229 hasIssue "1_Supplement" @default.
- W4313384229 hasLocation W43133842291 @default.
- W4313384229 hasOpenAccess W4313384229 @default.
- W4313384229 hasPrimaryLocation W43133842291 @default.
- W4313384229 hasRelatedWork W1557803273 @default.
- W4313384229 hasRelatedWork W2081996451 @default.
- W4313384229 hasRelatedWork W2138864047 @default.
- W4313384229 hasRelatedWork W2159359450 @default.
- W4313384229 hasRelatedWork W2262741309 @default.
- W4313384229 hasRelatedWork W2366649094 @default.
- W4313384229 hasRelatedWork W2384344522 @default.
- W4313384229 hasRelatedWork W2767749856 @default.
- W4313384229 hasRelatedWork W2980365702 @default.
- W4313384229 hasRelatedWork W2995822774 @default.
- W4313384229 hasVolume "200" @default.
- W4313384229 isParatext "false" @default.
- W4313384229 isRetracted "false" @default.
- W4313384229 workType "article" @default.