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- W4313384390 abstract "Abstract Elucidation of molecular mechanism underlying the inhibited infiltration effector function of T cells induced is essential for improvement of anti-tumor immunotherapy. Here, we found that Calnexin, a ER chaperon protein, is significantly up-regulated in OSCC tumor cells and multiple other tumors. Up-regulation of Clanexin in tumor cell membrane links with limited infiltration of T cells in OSCC tumor core and poorer survival of OSCC patients. Importantly, we found that Calnexin mediates inhibition of proliferation of CD4+ and CD8+T cells and effector functions of expression of IFN-γ, TNF-α, IL-2 by T cells. While knock-down of Calnexin enhanced the infiltration and effector functions of T cells in tumor cores and conferred better control of tumor growth, treatment of recombinant Calnexin induced impairment of infiltration and effector functions of T cells in tumor cores and promotes tumor growth in mice. Thus, this work uncovers a previously unknown mechanism in which infiltration of T cells and effector functions of T cells are inhibited by Calnexin expressed in tumor cells, and implicates that Calnexin may serve as an important target for improvement anti-tumor immunotherapy." @default.
- W4313384390 created "2023-01-06" @default.
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- W4313384390 date "2017-05-01" @default.
- W4313384390 modified "2023-10-05" @default.
- W4313384390 title "Calnexin induces impairment of proliferation and effector function of CD4+ and CD8+ T cells and promotes tumor growth" @default.
- W4313384390 doi "https://doi.org/10.4049/jimmunol.198.supp.196.6" @default.
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