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- W4313384432 abstract "Abstract Mesenchymal stem cells have the capacity to maintain immune homeostasis and prevent autoimmunity. We recently reported that human-derived gingival mesenchymal stem cells (GMSCs) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis in animals. However, it is unclear whether these cells can suppress human T cell-mediated diseases. Here, we used a xeno-GVHD model in the NOD/SCID mouse, which is a useful preclinical construct for evaluating the therapeutic and translational potential of this approach for applications in human disease. We found that GMSCs potently suppressed the proliferation of PBMC and T cells in vitro. Co-transfer of GMSC with human PBMC significantly suppressed human cell engraftment and markedly prolonged the mouse survival. Moreover, we demonstrated that GMSCs inhibited human PBMC-initiated xenogenic responses via CD39 and IDO signals. These findings suggest the potential for GMSCs to suppress human immune responses in immune system-mediated diseases, offering a potential clinical option to be used for modulating GVHD and autoimmune diseases." @default.
- W4313384432 created "2023-01-06" @default.
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- W4313384432 date "2017-05-01" @default.
- W4313384432 modified "2023-09-23" @default.
- W4313384432 title "Human gingiva-derived mesenchymal stem cells inhibit xeno-graft-versus-host disease through CD39 and IDO signals" @default.
- W4313384432 doi "https://doi.org/10.4049/jimmunol.198.supp.80.2" @default.
- W4313384432 hasPublicationYear "2017" @default.
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