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- W4313384729 abstract "Abstract Invariant natural killer T cells (iNKT) are a population of innate-like T lymphocytes that have crucial roles in protective responses to infectious agents, particularly Streptococcus pneumoniae. Despite their abundance in the lungs, there is limited understanding of how iNKT cells mediate protection there. Prior work from our group has shown that after pulmonary S. pneumoniae infection, iNKT cells are rapidly activated in a CD1d-dependent manner. Further, others have defined iNKT1, 2, and 17 cell subsets, analogous to CD4+ Th1, Th2, and Th17 subsets. In this study we investigated the roles of lung iNKT cell subsets in protection from S. pneumoniae. In naïve C57BL/6 mouse lungs, we found NKT1 and NKT17 cells were the predominant iNKT cell subsets, with most NKT17 cells in the tissue and NKT1 cells in both the tissue and vasculature. We then utilized fluorescent bacteria, flow cytometry, and intravital microscopy to analyze the lungs during pulmonary infection. At 24 hours, the bacteria localized within the tissue, and were taken up primarily by alveolar macrophages and neutrophils. At 14 and 24 hours, a majority of the lung NKT17 cells were producing IL-17, while only a minor percentage of NKT1 cells were producing IFNγ. This correlated with data from Nur77GFP reporter mice that indicate TCR-mediated activation. At 24 hours, approximately 75% of NKT17 but only 30% of NKT1 cells had been TCR-activated; suggesting NKT17 cells may play a dominant role early in infection. Yet, by 24 hours, NKT1 cells expanded to become the major subset in the lungs, proposing they are also relevant for protection. Experiments are underway to determine when and where subsets are first activated, roles of other cytokines, and consequences of removing individual subsets." @default.
- W4313384729 created "2023-01-06" @default.
- W4313384729 creator A5023137852 @default.
- W4313384729 creator A5052827209 @default.
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- W4313384729 date "2017-05-01" @default.
- W4313384729 modified "2023-09-27" @default.
- W4313384729 title "NKT cell subsets involved in host defense from pulmonary <i>Streptococcus pneumoniae</i> infection" @default.
- W4313384729 doi "https://doi.org/10.4049/jimmunol.198.supp.131.24" @default.
- W4313384729 hasPublicationYear "2017" @default.
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