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- W4313384767 abstract "Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by high levels of autoantibodies and multi-organ tissue damage. Although neuropsychiatric symptoms are frequent in patients with SLE, its pathogenesis remains unclear. In this study, we investigated pathogenesis of neuropsychiatric symptoms in SLE patients. We analyzed the medical records of 1131 patients with SLE and conducted animal experiments. We found that fifty-nine patients showed NPSLE clinical manifestation including headaches, seizure disorder, cognitive dysfunction, cerebrovascular disease, etc. Lupus-prone mice spontaneously develop meningitis and apoptosis of neurons. IgG is a major contributor in meningitis. This meningitis depends on the dose of IgG, but is not associated with the kind of autoantibody and disease activity. Monocyte/macrophage and TNF play important role in the development of this meningitis. Lupus IgG induces the apoptosis of neurons directly. The deposited IgG in brain tissue exerts an important role in the pathogenesis of NPSLE. This finding will promote the development of an effective therapeutic strategy for NPSLE patients." @default.
- W4313384767 created "2023-01-06" @default.
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- W4313384767 date "2017-05-01" @default.
- W4313384767 modified "2023-09-25" @default.
- W4313384767 title "Neuropsychiatric symptoms of patients with systemic lupus erythematosus caused by intracisternal deposited lupus IgG through meningitis" @default.
- W4313384767 doi "https://doi.org/10.4049/jimmunol.198.supp.55.3" @default.
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