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- W4313384805 abstract "Abstract Tissue-resident memory T (TRM) cells play an important role in protection against re-occurring infection. Compared with circulating memory T cells, tissue-specific TRM cells have great advantages in mounting faster and more effective responses against local infections. Female reproductive tract (FRT), which is a portal of entry for sexually transmitted infections, is an immunologically restrictive tissue that prevents progenitors of TRM cells entering in the absence of inflammation or infection. Therefore, how to increase number of TRM cells in FRT after vaccination to improve memory response against pathogens becomes an important question. In our present study, we found that a significant portion of T cells in FRT expressed the skin-homing chemokine receptor CCR10 in physiological conditions, and those CCR10+ T cells displayed surface markers typical for TRM cells. Particularly, almost all the CCR10+ CD8+ T cells expressed CXCR3, a homing marker which could help T cell migrate into FRT, suggesting the competition of skin and FRT for CD8+ T cells. After epicutaneous immunization, activated antigen-specific CCR10-knockout CD8+ T cells migrated more efficiently into FRT than CCR10-sufficient T cells. Our finding suggests that blocking CCR10 signals could divert skin-homing T cells into FRT for enhanced establishment of local resident memory T cells." @default.
- W4313384805 created "2023-01-06" @default.
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- W4313384805 date "2017-05-01" @default.
- W4313384805 modified "2023-09-28" @default.
- W4313384805 title "Blocking CCR10 diverts skin-homing T cells to reproductive tract for enhanced establishment of local resident memory T cells" @default.
- W4313384805 doi "https://doi.org/10.4049/jimmunol.198.supp.149.11" @default.
- W4313384805 hasPublicationYear "2017" @default.
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