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- W4313384928 abstract "Abstract Patients with early stage cancer do not usually die from primary cancer, which tends to be responsive to therapy, but rather as a result of distant recurrence of the tumor in the form of advanced stage diseases. This phenomenon can be explained by cancer dormancy. However, many patients that harbor dormant tumor cells survive without experiencing recurrence. It has been suggested that certain chemotherapeutics that induce immunogenic tumor cell death (ICD) could prolong survival of patients because of inducing an anti-tumor immune response. However, tumor-reactive immune cells might fade away due to toxic doses of chemotherapy and/or tolerogenic properties of dormant tumor cells. Here, we hypothesize that some chemotherapeutic drugs at a low dose could also induce immunogenic tumor dormancy (ITD) for constant stimulation of the immune system. To test our hypothesis, we used neu overexpressing mouse mammary carcinoma (MMC) cells, and different doses of Adriamycin, Cyclophosphamide, or a combination therapy of 5-flurouracil, Adriamycin, and Cyclophosphamide (FAC). We demonstrated that low dose FAC was more effective in inducing ICD and ITD compared with other drugs or more cytotoxic doses. These findings warrant further examination into using a conditioning regimen of low-dose chemotherapeutics as a means of establishing ICD and ITD, thereby inducing and maintaining an immune response for the prevention of tumor recurrence." @default.
- W4313384928 created "2023-01-06" @default.
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- W4313384928 date "2017-05-01" @default.
- W4313384928 modified "2023-09-23" @default.
- W4313384928 title "Low-dose chemotherapy induces immunogenic tumor dormancy in mouse mammary carcinoma cells" @default.
- W4313384928 doi "https://doi.org/10.4049/jimmunol.198.supp.204.14" @default.
- W4313384928 hasPublicationYear "2017" @default.
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