Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313384954> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4313384954 endingPage "123.8" @default.
- W4313384954 startingPage "123.8" @default.
- W4313384954 abstract "Abstract Cryptococcus neoformans is a pathogenic encapsulated fungus and a leading cause of fatal meningitis in immunocompromised individuals. IL-27 is a recently identified cytokine affecting both innate and adaptive immunity. Both proinflammatory and inhibitory functions on T cells by IL-27 have been reported in different disease models. Nevertheless, the effect of IL-27 during Cryptococcus infection has never been studied. In current study, IL-27 receptor alpha knockout mice (IL27R KO) was infected with a high virulent cryptococcal strain. We found that mice deficient in IL-27 signaling have significantly increased fungal burden in the lung and shortened survival time. Surprisingly, infected IL-27R KO mice showed unchanged Th1 and Th17 cytokines but significantly reduced Th2 cytokines including IL-4, IL-5 and IL-13. The reduced Th2 response is unlikely to be a cause of increase fungal burden since Th2 was generally known as detrimental during Cryptococcus infection. We next studied the immune cell composition by flow cytometry, no difference in cell number was found for all cell types except neutrophil which is increased during infection indicating more inflammation. The increase of neutrophils is associated with increased chemokines KC and MIP-2. Cryptococcus infection causes sustained production of TNF alpha, we next found that IL-27 suppressed the chemokine release by immune cells as a response to TNF-alpha. Lastly, depletion of neutrophils improved the outcome in infected IL-27R KO mice proving that immune pathology mediated by neutrophils can be detrimental during Cryptococcus infection." @default.
- W4313384954 created "2023-01-06" @default.
- W4313384954 creator A5001150568 @default.
- W4313384954 creator A5037615904 @default.
- W4313384954 creator A5074269063 @default.
- W4313384954 date "2017-05-01" @default.
- W4313384954 modified "2023-09-23" @default.
- W4313384954 title "IL-27 limits neutrophil mediated pathology during pulmonary infection with <i>Cryptococcus neoformans</i>" @default.
- W4313384954 doi "https://doi.org/10.4049/jimmunol.198.supp.123.8" @default.
- W4313384954 hasPublicationYear "2017" @default.
- W4313384954 type Work @default.
- W4313384954 citedByCount "1" @default.
- W4313384954 countsByYear W43133849542023 @default.
- W4313384954 crossrefType "journal-article" @default.
- W4313384954 hasAuthorship W4313384954A5001150568 @default.
- W4313384954 hasAuthorship W4313384954A5037615904 @default.
- W4313384954 hasAuthorship W4313384954A5074269063 @default.
- W4313384954 hasConcept C13373296 @default.
- W4313384954 hasConcept C136449434 @default.
- W4313384954 hasConcept C164027704 @default.
- W4313384954 hasConcept C17991360 @default.
- W4313384954 hasConcept C193419808 @default.
- W4313384954 hasConcept C203014093 @default.
- W4313384954 hasConcept C2776914184 @default.
- W4313384954 hasConcept C2777893358 @default.
- W4313384954 hasConcept C2778690821 @default.
- W4313384954 hasConcept C2778952914 @default.
- W4313384954 hasConcept C2779341262 @default.
- W4313384954 hasConcept C2779413141 @default.
- W4313384954 hasConcept C553184892 @default.
- W4313384954 hasConcept C86803240 @default.
- W4313384954 hasConcept C8891405 @default.
- W4313384954 hasConcept C89423630 @default.
- W4313384954 hasConceptScore W4313384954C13373296 @default.
- W4313384954 hasConceptScore W4313384954C136449434 @default.
- W4313384954 hasConceptScore W4313384954C164027704 @default.
- W4313384954 hasConceptScore W4313384954C17991360 @default.
- W4313384954 hasConceptScore W4313384954C193419808 @default.
- W4313384954 hasConceptScore W4313384954C203014093 @default.
- W4313384954 hasConceptScore W4313384954C2776914184 @default.
- W4313384954 hasConceptScore W4313384954C2777893358 @default.
- W4313384954 hasConceptScore W4313384954C2778690821 @default.
- W4313384954 hasConceptScore W4313384954C2778952914 @default.
- W4313384954 hasConceptScore W4313384954C2779341262 @default.
- W4313384954 hasConceptScore W4313384954C2779413141 @default.
- W4313384954 hasConceptScore W4313384954C553184892 @default.
- W4313384954 hasConceptScore W4313384954C86803240 @default.
- W4313384954 hasConceptScore W4313384954C8891405 @default.
- W4313384954 hasConceptScore W4313384954C89423630 @default.
- W4313384954 hasIssue "1_Supplement" @default.
- W4313384954 hasLocation W43133849541 @default.
- W4313384954 hasOpenAccess W4313384954 @default.
- W4313384954 hasPrimaryLocation W43133849541 @default.
- W4313384954 hasRelatedWork W1557621914 @default.
- W4313384954 hasRelatedWork W1841503726 @default.
- W4313384954 hasRelatedWork W2103515427 @default.
- W4313384954 hasRelatedWork W2131232351 @default.
- W4313384954 hasRelatedWork W2132317181 @default.
- W4313384954 hasRelatedWork W2133765154 @default.
- W4313384954 hasRelatedWork W2792327733 @default.
- W4313384954 hasRelatedWork W3009029317 @default.
- W4313384954 hasRelatedWork W3029855245 @default.
- W4313384954 hasRelatedWork W3206943983 @default.
- W4313384954 hasVolume "198" @default.
- W4313384954 isParatext "false" @default.
- W4313384954 isRetracted "false" @default.
- W4313384954 workType "article" @default.