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- W4313385003 abstract "Abstract Invariant NKT (iNKT) cells are a distinct subset of T cells that exert Janus-like functions in vivo by producing IFN-γ and IL-4. Sodium chloride modulates the functions of various immune cells, including conventional CD4+ T cells and macrophages. However, it is not known whether sodium chloride affects iNKT cell function, so we addressed this issue. Sodium chloride inhibited IFN-γ, but not IL-4, production by iNKT cells upon TCR stimulation in a dose-dependent manner. Consistently, sodium chloride reduced the expression level of t-bet, but not gata-3, in iNKT cells stimulated with TCR engagement. Sodium chloride increased phosphorylated p38 expression in iNKT cells and inhibitors of p38 and NFAT5, and SGK1 restored IFN-γ production by iNKT cells stimulated with sodium chloride and TCR engagement. Furthermore, adoptive transfer of iNKT cells pretreated with sodium chloride restored antibody-induced joint inflammation to a lesser extent than for untreated iNKT cells in Jα18 knockout mice. These findings suggest that sodium chloride inhibits IFN-γ production by iNKT cells upon TCR stimulation, which is dependent on p38, NFAT5, and SGK1. These findings highlight the functional role of sodium chloride in iNKT cell-mediated inflammatory diseases." @default.
- W4313385003 created "2023-01-06" @default.
- W4313385003 creator A5030895412 @default.
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- W4313385003 date "2017-05-01" @default.
- W4313385003 modified "2023-09-27" @default.
- W4313385003 title "Sodium chloride inhibits IFN-γ, but not IL-4, production by invariant NKT cells" @default.
- W4313385003 doi "https://doi.org/10.4049/jimmunol.198.supp.52.24" @default.
- W4313385003 hasPublicationYear "2017" @default.
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