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- W4313385067 abstract "Abstract ALVAC-SIV/gp120 vaccine reduced the risk of infection in SIVmac251 model. Protection was associated with antibodies (Abs) to V2 region of gp120 protein, mucosal NKp44+ cells, and the expression of 11 genes in the Ras pathway. IGF-1 hormone is a Ras activator and its plasma level diminishes with aging. We hypothesized that IGF-1 might affect the efficacy of the ALVAC-SIV/gp120 platform by modulating the immune responses, particularly when administered in old macaques. In this study we enrolled 25 young (Group 1, av. 3 years) and 34 old macaques (Group 2, av. 9 years) having significantly different plasma levels of IGF-1, and we immunized them with a DNA-SIV/ALVAC-SIV/gp120 vaccine. During immunizations, half of the animals of each group were also administered IGF-1, as recombinant protein (Increlex, Ipsen) and as DNA vaccine. All the animals, including controls, were challenged intra-vaginally with repeated low-doses of SIVmac251. The estimated vaccine efficacy in young macaques of Group 1 was 69%. IGF-1 administration did not increase the efficacy; although, it determined a significant increase of serum Abs titers against V2 and frequency of mucosal NKp44+ cells. Furthermore, IGF-1 treated macaques showed higher frequencies of circulating classical (CCR2+CD14+CD16−) and intermediate (CCR2+CD14+CD16+) monocytes and lower frequencies of mucosal CD4+ T cells expressing α4β7 or CCR5 compared to the untreated animals. These data suggest that IGF-1 administration might improve protective immune responses and decrease possible SIV target cells in the mucosa. Therefore, IGF-1 administration during vaccination might particularly benefit older animals. Challenge exposure of older animals in Group 2 is ongoing." @default.
- W4313385067 created "2023-01-06" @default.
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- W4313385067 date "2017-05-01" @default.
- W4313385067 modified "2023-09-26" @default.
- W4313385067 title "Modulation of DNA/ALVAC/gp120 vaccine immune-response by vaccination with Insulin-Like Growth Factor 1 (IGF-1)" @default.
- W4313385067 doi "https://doi.org/10.4049/jimmunol.198.supp.225.17" @default.
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