Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385087> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4313385087 endingPage "73.14" @default.
- W4313385087 startingPage "73.14" @default.
- W4313385087 abstract "Abstract A significant challenge to HIV eradication is the elimination of viral reservoirs in germinal center (GC) resident T follicular helper cells. Therapeutic interventions that target viral reservoirs should induce anti-viral CD8 T cells that home to GC. We and others recently described a unique population of CD8 T cells that express the chemokine receptor CXCR5 (required for homing to GC) during chronic HIV/SIV infections. A critical question that remains to be addressed is if follicular homing CD8 T cells can be induced by vaccination and if so how will they impact control of HIV. Here we show that vaccination of rhesus macaques (RM) with DNA/MVA (modified vaccinia Ankara) SHIV vaccine induces low levels of vaccine-specific CXCR5+ CD8 T cells in blood. However, adjuvanting the DNA vaccine with CD40L dramatically enhanced the induction of CXCR5+ SHIV-specific CD8 T cells up to 10-fold with a frequency of about 5% of total CD8. These CXCR5+ CD8 T cells expressed higher levels of cytolytic molecules perforin and granzyme-B with higher proliferative capacity (ki-67) compared to CXCR5-subset. Following a pathogenic SHIV infection, the CXCR5+ CD8 subset expanded rapidly. Importantly, the frequency of SHIV-specific CXCR5+ CD8 T cells post vaccination and post infection showed a significant inverse correlation with viral load (p=0.003, R=−0.66), these associations were not observed with CXCR5-CD8 T cells. These data demonstrate that CXCR5+ CD8 T cells can be induced by vaccination, their induction can be augmented by CD40L, and the vaccine-induced CXCR5+ CD8 T cells contribute to control of pathogenic immunodeficiency virus infection. These findings have important implications for developing HIV cure strategies." @default.
- W4313385087 created "2023-01-06" @default.
- W4313385087 creator A5021170522 @default.
- W4313385087 creator A5035756733 @default.
- W4313385087 creator A5037965962 @default.
- W4313385087 creator A5053252368 @default.
- W4313385087 creator A5078906487 @default.
- W4313385087 creator A5082333959 @default.
- W4313385087 date "2017-05-01" @default.
- W4313385087 modified "2023-09-26" @default.
- W4313385087 title "Induction of CXCR5+ follicular CD8 T cells by CD40L adjuvanted DNA/MVA vaccination is associated with enhanced control of pathogenic SHIV infection." @default.
- W4313385087 doi "https://doi.org/10.4049/jimmunol.198.supp.73.14" @default.
- W4313385087 hasPublicationYear "2017" @default.
- W4313385087 type Work @default.
- W4313385087 citedByCount "1" @default.
- W4313385087 countsByYear W43133850872018 @default.
- W4313385087 crossrefType "journal-article" @default.
- W4313385087 hasAuthorship W4313385087A5021170522 @default.
- W4313385087 hasAuthorship W4313385087A5035756733 @default.
- W4313385087 hasAuthorship W4313385087A5037965962 @default.
- W4313385087 hasAuthorship W4313385087A5053252368 @default.
- W4313385087 hasAuthorship W4313385087A5078906487 @default.
- W4313385087 hasAuthorship W4313385087A5082333959 @default.
- W4313385087 hasConcept C154317977 @default.
- W4313385087 hasConcept C159047783 @default.
- W4313385087 hasConcept C159654299 @default.
- W4313385087 hasConcept C167672396 @default.
- W4313385087 hasConcept C202751555 @default.
- W4313385087 hasConcept C203014093 @default.
- W4313385087 hasConcept C22070199 @default.
- W4313385087 hasConcept C2776708503 @default.
- W4313385087 hasConcept C2778190748 @default.
- W4313385087 hasConcept C2778453870 @default.
- W4313385087 hasConcept C2780195530 @default.
- W4313385087 hasConcept C55493867 @default.
- W4313385087 hasConcept C86803240 @default.
- W4313385087 hasConcept C8891405 @default.
- W4313385087 hasConcept C96926380 @default.
- W4313385087 hasConceptScore W4313385087C154317977 @default.
- W4313385087 hasConceptScore W4313385087C159047783 @default.
- W4313385087 hasConceptScore W4313385087C159654299 @default.
- W4313385087 hasConceptScore W4313385087C167672396 @default.
- W4313385087 hasConceptScore W4313385087C202751555 @default.
- W4313385087 hasConceptScore W4313385087C203014093 @default.
- W4313385087 hasConceptScore W4313385087C22070199 @default.
- W4313385087 hasConceptScore W4313385087C2776708503 @default.
- W4313385087 hasConceptScore W4313385087C2778190748 @default.
- W4313385087 hasConceptScore W4313385087C2778453870 @default.
- W4313385087 hasConceptScore W4313385087C2780195530 @default.
- W4313385087 hasConceptScore W4313385087C55493867 @default.
- W4313385087 hasConceptScore W4313385087C86803240 @default.
- W4313385087 hasConceptScore W4313385087C8891405 @default.
- W4313385087 hasConceptScore W4313385087C96926380 @default.
- W4313385087 hasIssue "1_Supplement" @default.
- W4313385087 hasLocation W43133850871 @default.
- W4313385087 hasOpenAccess W4313385087 @default.
- W4313385087 hasPrimaryLocation W43133850871 @default.
- W4313385087 hasRelatedWork W115132872 @default.
- W4313385087 hasRelatedWork W155301942 @default.
- W4313385087 hasRelatedWork W1991837516 @default.
- W4313385087 hasRelatedWork W2019574320 @default.
- W4313385087 hasRelatedWork W2143941734 @default.
- W4313385087 hasRelatedWork W2921028124 @default.
- W4313385087 hasRelatedWork W3048051248 @default.
- W4313385087 hasRelatedWork W3180719608 @default.
- W4313385087 hasRelatedWork W4206914007 @default.
- W4313385087 hasRelatedWork W4221063257 @default.
- W4313385087 hasVolume "198" @default.
- W4313385087 isParatext "false" @default.
- W4313385087 isRetracted "false" @default.
- W4313385087 workType "article" @default.