Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385103> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313385103 endingPage "130.6" @default.
- W4313385103 startingPage "130.6" @default.
- W4313385103 abstract "Abstract Natural killer (NK) cells are important effectors of the immune system that can lyse malignancy-transformed cells. In the human liver, NK cells can account up to 50% of the total lymphocyte population. How NK cells lose immune surveillance occurs in hepatocellular carcinoma progression. In this study, 75 cases from hepatocellular carcinoma (HCC) patients were analyzed by RNA sequence, pathology, flow cytometry and cell culture in vitro. We found a significant enrichment of infiltrating T cells within the tumor tissues of HCC patients but not NK cells, as compared to the adjacent peritumoral tissues. It is interesting that the infiltrating NK cells enrich CD56brightCD49a+ NK subset, like liver-resident NK. Nearly 50% of the entire healthy liver NK cell population is composed of functionally relevant CD56bright CD49a-NK cells, and almost all of the subset was lose. The infiltrating CD56brightCD49a+ NK cells present exhausted phenotype and downregulated expression of efficacy molecules of CD11b, CD226 and IFN-γ. We also found a few of CD56dimCD16+ NK cells were infiltrating, which were similar to their peripheral circulating counterparts in transcription and phenotype, but the lower effect function and viability of infiltrating NK cells compared with normal liver or peripheral circulating counterparts. Dynamic reprogramming of metabolism is essential for immune cell stable liveness and effector function. Gene Ontology profiling and metabolism analysis revealed the infiltrating NK cells bioenergetic insufficiencies and enrichment of metabolic oxygen specis leading to its subset variations and immune surveillance insensitivity." @default.
- W4313385103 created "2023-01-06" @default.
- W4313385103 creator A5035317876 @default.
- W4313385103 creator A5054383087 @default.
- W4313385103 creator A5083130438 @default.
- W4313385103 creator A5084047711 @default.
- W4313385103 date "2017-05-01" @default.
- W4313385103 modified "2023-09-26" @default.
- W4313385103 title "Tumorous niche drives NK exhaustion by disordering metabolic program" @default.
- W4313385103 doi "https://doi.org/10.4049/jimmunol.198.supp.130.6" @default.
- W4313385103 hasPublicationYear "2017" @default.
- W4313385103 type Work @default.
- W4313385103 citedByCount "0" @default.
- W4313385103 crossrefType "journal-article" @default.
- W4313385103 hasAuthorship W4313385103A5035317876 @default.
- W4313385103 hasAuthorship W4313385103A5054383087 @default.
- W4313385103 hasAuthorship W4313385103A5083130438 @default.
- W4313385103 hasAuthorship W4313385103A5084047711 @default.
- W4313385103 hasConcept C129374314 @default.
- W4313385103 hasConcept C149532602 @default.
- W4313385103 hasConcept C154317977 @default.
- W4313385103 hasConcept C182676581 @default.
- W4313385103 hasConcept C183315844 @default.
- W4313385103 hasConcept C196166836 @default.
- W4313385103 hasConcept C202751555 @default.
- W4313385103 hasConcept C203014093 @default.
- W4313385103 hasConcept C206191192 @default.
- W4313385103 hasConcept C2776090121 @default.
- W4313385103 hasConcept C28651165 @default.
- W4313385103 hasConcept C2908647359 @default.
- W4313385103 hasConcept C502942594 @default.
- W4313385103 hasConcept C553184892 @default.
- W4313385103 hasConcept C55493867 @default.
- W4313385103 hasConcept C71924100 @default.
- W4313385103 hasConcept C86803240 @default.
- W4313385103 hasConcept C8891405 @default.
- W4313385103 hasConcept C95444343 @default.
- W4313385103 hasConcept C99454951 @default.
- W4313385103 hasConceptScore W4313385103C129374314 @default.
- W4313385103 hasConceptScore W4313385103C149532602 @default.
- W4313385103 hasConceptScore W4313385103C154317977 @default.
- W4313385103 hasConceptScore W4313385103C182676581 @default.
- W4313385103 hasConceptScore W4313385103C183315844 @default.
- W4313385103 hasConceptScore W4313385103C196166836 @default.
- W4313385103 hasConceptScore W4313385103C202751555 @default.
- W4313385103 hasConceptScore W4313385103C203014093 @default.
- W4313385103 hasConceptScore W4313385103C206191192 @default.
- W4313385103 hasConceptScore W4313385103C2776090121 @default.
- W4313385103 hasConceptScore W4313385103C28651165 @default.
- W4313385103 hasConceptScore W4313385103C2908647359 @default.
- W4313385103 hasConceptScore W4313385103C502942594 @default.
- W4313385103 hasConceptScore W4313385103C553184892 @default.
- W4313385103 hasConceptScore W4313385103C55493867 @default.
- W4313385103 hasConceptScore W4313385103C71924100 @default.
- W4313385103 hasConceptScore W4313385103C86803240 @default.
- W4313385103 hasConceptScore W4313385103C8891405 @default.
- W4313385103 hasConceptScore W4313385103C95444343 @default.
- W4313385103 hasConceptScore W4313385103C99454951 @default.
- W4313385103 hasIssue "1_Supplement" @default.
- W4313385103 hasLocation W43133851031 @default.
- W4313385103 hasOpenAccess W4313385103 @default.
- W4313385103 hasPrimaryLocation W43133851031 @default.
- W4313385103 hasRelatedWork W1560116787 @default.
- W4313385103 hasRelatedWork W2007333986 @default.
- W4313385103 hasRelatedWork W2017791892 @default.
- W4313385103 hasRelatedWork W2049687639 @default.
- W4313385103 hasRelatedWork W2074969559 @default.
- W4313385103 hasRelatedWork W2120377306 @default.
- W4313385103 hasRelatedWork W2571232265 @default.
- W4313385103 hasRelatedWork W2801411950 @default.
- W4313385103 hasRelatedWork W2804682433 @default.
- W4313385103 hasRelatedWork W4313385103 @default.
- W4313385103 hasVolume "198" @default.
- W4313385103 isParatext "false" @default.
- W4313385103 isRetracted "false" @default.
- W4313385103 workType "article" @default.