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- W4313385105 abstract "Abstract Airway obstruction is a highly specific term that represents physiologic abnormalities of the airways and induced levels is observed in steroid treated asthmatic patients. We tested the hypothesis that regulation of IL-15 is critical for the preservation of allergen-induced airway hyperresponsiveness (AHR), airway resistance and compliance in response to methacholine. Airway inflammation, AHR, resistance and compliance were assessed in IL-15-deficient mice and IL-15 overexpressed mice in allergen-induced murine model of asthma. Lung histological analysis for eosinophils by anti-MBP immunostaining, Goblet cells hyperplasia by PAS staining, cytokines and chemokine levels by qPCR and ELISA analyses. Herein, we made a novel observation that IL-15 deficiency promotes baseline airway resistance in naïve mice. Moreover, rIL-15 delivery to the lung downregulates expression of inflammatory cytokines, and improves allergen-induced AHR, resistance and compliance. These observations were further validated in DOX-inducible CC-10-IL-15 transgenic mice. DOX exposed Aspergillus extract challenged CC-10-IL-15 bitransgenic mice exhibited significantly reduced levels of inflammatory cytokines (IL-4, IL-5, IL-13) and goblet cell hyperplasia. Airway obstruction, including AHR and resistance was diminished in allergen challenged DOX exposed compare to no-DOX exposed CC-10-IL-15 bitransgenic mice. Mechanistically, we observed that IL-15-induced protection of airway obstruction is associated with the induced IL-10-producing regulatory CD4+CD25+Foxp3+ T cells. We report our novel finding that IL-15 has a potent inhibitory effect on the airway obstruction that occurs in response to environmental allergens/pollutants." @default.
- W4313385105 created "2023-01-06" @default.
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- W4313385105 date "2017-05-01" @default.
- W4313385105 modified "2023-10-12" @default.
- W4313385105 title "Regulatory effects of Interleukin (IL)-15 on allergen-induced airway obstruction" @default.
- W4313385105 doi "https://doi.org/10.4049/jimmunol.198.supp.53.1" @default.
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