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- W4313385144 abstract "Abstract Abdominal aortic aneurysm (AAA) is a macrophage-mediated chronic inflammatory disease. Aortic mural macrophages arise from bone marrow-derived circulating monocytes, recruited to the aneurysmal aorta by CCL2/CCR2 signaling. Given the importance of mesenchymal stem cell (MSC)-derived CCL2 in bone marrow monocyte mobilization, we hypothesized that MSC-derived CCL2 contributes to AAA pathogenesis. AAAs were created in 10–12 weeks old, male MSC-specific CCL2 knockout (Nestin+/CCL2 Flox+/+) and wild type (CCL2 Flox+/+) mice via intra-aortic elastase infusion. AAA incidence and progression were assessed via serial in vivo ultrasound aortic diameter measurements and histopathological analysis at sacrifice. MSC cell-specific CCL2 ablation significantly reduced circulating Ly-6Chigh inflammatory monocytes at baseline as well as 3 hours following lipopolysaccharide injection. Following elastase infusion, wild type mice demonstrated progressive, time-dependent aortic enlargement beginning on day 3. In MSC-specific CCL2 knockout mice, elastase-induced aortic enlargement was substantially suppressed, and medial elastin lamellae and smooth muscle cell cellularity were preserved compared to that demonstrated in wild type AAA mice. Mural macrophages, T and B cell infiltration were all also significantly attenuated in knockout, as compared to wild type, mice. Additionally, aortic neoangiogenesis, as defined by mural CD31+ capillary vessel density, was significantly reduced in knockout mice. Taken together, this evidence suggests that MSC-specific CCL2 deletion suppresses progression of experimental AAAs, in conjunction with attenuation of aortic mural inflammation and angiogenesis." @default.
- W4313385144 created "2023-01-06" @default.
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- W4313385144 date "2017-05-01" @default.
- W4313385144 modified "2023-09-23" @default.
- W4313385144 title "Deletion of CCL2 in mesenchymal stem cells suppresses experimental aortic aneurysms" @default.
- W4313385144 doi "https://doi.org/10.4049/jimmunol.198.supp.69.3" @default.
- W4313385144 hasPublicationYear "2017" @default.
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