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- W4313385146 abstract "Abstract Infection with the influenza virus triggers an innate immune response aimed at limiting viral replication and spread. However, the molecular mechanism(s) underlying the processes of change–in innate immune cell homeostasis are not known. We show here that the influenza virus specifically alters the metabolism of dendritic cells (DCs) to enhance viral biomass production and that the metabolic response of the dendritic cells to viral infection differed from activation via TLR stimulation or infection with inactive virus. Using quantitative mass spectrometry along with pulse chase assay and metabolic flux measurements, we found that metabolic pathway changes dominated after infection, including increased glycolysis and glutaminolysis, and decreased tricarboxylic acid cycle and β-oxidation. This metabolic response to viral infection increased the expression of the c-Myc transcription factor, which indicates that influenza have the potential to induce key metabolic regulatory events. Influenza infection induces a unique metabolic signature in dendritic cells, prior to the canonical innate response to viral infection. Limiting these metabolic changes by metabolite restriction induces massive cell death in infected DCs, suggesting they play a vital role in initiating the innate immune response." @default.
- W4313385146 created "2023-01-06" @default.
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- W4313385146 date "2017-05-01" @default.
- W4313385146 modified "2023-09-26" @default.
- W4313385146 title "Coordinated metabolic response of dendritic cells to influenza infection" @default.
- W4313385146 doi "https://doi.org/10.4049/jimmunol.198.supp.148.4" @default.
- W4313385146 hasPublicationYear "2017" @default.
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