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- W4313385156 abstract "Abstract Polyfunctional T cells are critical for maintaining protection against pathogens. Patients with end-stage renal disease (ESRD) are at increased risks for infectious complications and their T cell immunity against viruses may be impaired. The current study intends to investigate the effects of renal disease on T cell immunity by analyzing T cell differentiation (based on expression of CCR7 and CD45RA) and polyfunctionality response against cytomegalovirus (CMV), an ubiquitous pathogen. Two CMV peptide pools (IE1 and pp65) were used to stimulate PBMCs and four effector functions were measured by multicolor flow cytometry (IL-2, TNFα, IFNγ and CD107a) to identify polyfunctional T cells. 17 healthy individuals, 13 patients with pre-dialysis chronic kidney disease (CKD) and 37 ESRD patients were enrolled in this study. All the donors were seropositive with an average age of 60. Patients with renal disease, especially the ESRD patients, showed increased levels of T cell differentiation, including the decrease in CD4+ and CD8+ TN cells and the increase in the CD4+ and CD8+ TEM and TEMRA cells. While the cellular frequency of CMV-reactive CD4+ and CD8+ T cells were similar among different groups, polyfunctional cell were dramatically reduced in ESRD. Among healthy individuals, CKD and ESRD patients, CD4+ CMV-IE1-reactive polyfunctional cell frequencies were 2.0%, 2.2%, and 0%, respectively (p=0.002). The CD8+ CMV-pp65-reactive polyfunctional cell frequencies were 12.4%, 8.8% and 0.8% in the three groups (p<0.001). Such phenomenon resembles T cell exhaustion observed in HIV infection and further studies should investigate the level of inhibitory receptor expression levels such as PD-1 and CTLA-4 in these patients." @default.
- W4313385156 created "2023-01-06" @default.
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- W4313385156 date "2017-05-01" @default.
- W4313385156 modified "2023-09-23" @default.
- W4313385156 title "Lack of polyfunctional cytomegalovirus-specific T cells in hemodialysis patients" @default.
- W4313385156 doi "https://doi.org/10.4049/jimmunol.198.supp.212.3" @default.
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