Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385158> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313385158 endingPage "65.3" @default.
- W4313385158 startingPage "65.3" @default.
- W4313385158 abstract "Abstract Group 3 innate lymphoid cells (ILC3) have been recently implicated in various autoimmune conditions including inflammatory bowel diseases (IBD). The mechanisms by which ILC3s contibute to IBD pathogenesis remain elusive. In this study, using genetic deleletions that impact ILC3s to varying degrees we sought to determine their contribution to murine IBD development. We show that IL-23-dependent T cell-induced colitis develops independently of ILC3s. Host IL-2 receptor common γ chain (IL-2Rγc) is needed for both innate and adaptive cell-driven colitis, since its deficiency impairs colitogenic T cell proliferation, expansion and recruitment to intestines. We also provide evidence that resistance to colitis in IL-2Rγc Rag2−/− mice may occur as a result of defective IL-15R signaling, and that IL–15−/− Rag1−/− mice recapitulates the murine IBD phenotype of IL-2Rγc Rag2−/− mice. Data we presented herein demonstrates that IL-15 plays an important role in IBD pathogenesis and may contribute to gut inflammation by regulating IL-23 production of antigen presenting cells." @default.
- W4313385158 created "2023-01-06" @default.
- W4313385158 creator A5002403603 @default.
- W4313385158 creator A5005662141 @default.
- W4313385158 creator A5013379630 @default.
- W4313385158 creator A5016490827 @default.
- W4313385158 creator A5046485872 @default.
- W4313385158 creator A5050045453 @default.
- W4313385158 date "2017-05-01" @default.
- W4313385158 modified "2023-10-17" @default.
- W4313385158 title "IL-15 regulates IL-23 production and murine IBD-like disease" @default.
- W4313385158 doi "https://doi.org/10.4049/jimmunol.198.supp.65.3" @default.
- W4313385158 hasPublicationYear "2017" @default.
- W4313385158 type Work @default.
- W4313385158 citedByCount "0" @default.
- W4313385158 crossrefType "journal-article" @default.
- W4313385158 hasAuthorship W4313385158A5002403603 @default.
- W4313385158 hasAuthorship W4313385158A5005662141 @default.
- W4313385158 hasAuthorship W4313385158A5013379630 @default.
- W4313385158 hasAuthorship W4313385158A5016490827 @default.
- W4313385158 hasAuthorship W4313385158A5046485872 @default.
- W4313385158 hasAuthorship W4313385158A5050045453 @default.
- W4313385158 hasConcept C104317684 @default.
- W4313385158 hasConcept C142724271 @default.
- W4313385158 hasConcept C156695909 @default.
- W4313385158 hasConcept C193419808 @default.
- W4313385158 hasConcept C203014093 @default.
- W4313385158 hasConcept C2775862500 @default.
- W4313385158 hasConcept C2776090121 @default.
- W4313385158 hasConcept C2776914184 @default.
- W4313385158 hasConcept C2778260677 @default.
- W4313385158 hasConcept C2779134260 @default.
- W4313385158 hasConcept C2780942790 @default.
- W4313385158 hasConcept C2781376893 @default.
- W4313385158 hasConcept C47742525 @default.
- W4313385158 hasConcept C54355233 @default.
- W4313385158 hasConcept C71924100 @default.
- W4313385158 hasConcept C86803240 @default.
- W4313385158 hasConcept C8891405 @default.
- W4313385158 hasConceptScore W4313385158C104317684 @default.
- W4313385158 hasConceptScore W4313385158C142724271 @default.
- W4313385158 hasConceptScore W4313385158C156695909 @default.
- W4313385158 hasConceptScore W4313385158C193419808 @default.
- W4313385158 hasConceptScore W4313385158C203014093 @default.
- W4313385158 hasConceptScore W4313385158C2775862500 @default.
- W4313385158 hasConceptScore W4313385158C2776090121 @default.
- W4313385158 hasConceptScore W4313385158C2776914184 @default.
- W4313385158 hasConceptScore W4313385158C2778260677 @default.
- W4313385158 hasConceptScore W4313385158C2779134260 @default.
- W4313385158 hasConceptScore W4313385158C2780942790 @default.
- W4313385158 hasConceptScore W4313385158C2781376893 @default.
- W4313385158 hasConceptScore W4313385158C47742525 @default.
- W4313385158 hasConceptScore W4313385158C54355233 @default.
- W4313385158 hasConceptScore W4313385158C71924100 @default.
- W4313385158 hasConceptScore W4313385158C86803240 @default.
- W4313385158 hasConceptScore W4313385158C8891405 @default.
- W4313385158 hasIssue "1_Supplement" @default.
- W4313385158 hasLocation W43133851581 @default.
- W4313385158 hasOpenAccess W4313385158 @default.
- W4313385158 hasPrimaryLocation W43133851581 @default.
- W4313385158 hasRelatedWork W1498031631 @default.
- W4313385158 hasRelatedWork W1963802005 @default.
- W4313385158 hasRelatedWork W1993150527 @default.
- W4313385158 hasRelatedWork W2068666335 @default.
- W4313385158 hasRelatedWork W2069307976 @default.
- W4313385158 hasRelatedWork W2133765154 @default.
- W4313385158 hasRelatedWork W2165578318 @default.
- W4313385158 hasRelatedWork W3128930788 @default.
- W4313385158 hasRelatedWork W4241335203 @default.
- W4313385158 hasRelatedWork W4248746885 @default.
- W4313385158 hasVolume "198" @default.
- W4313385158 isParatext "false" @default.
- W4313385158 isRetracted "false" @default.
- W4313385158 workType "article" @default.