Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385192> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4313385192 endingPage "122.16" @default.
- W4313385192 startingPage "122.16" @default.
- W4313385192 abstract "Abstract Denguevirus is a mosquito-borne flavivirus that is comprised of four antigenically related but distinct serotypes. A higher risk for the most severe clinical manifestations of dengue infection, dengue fever and dengue hemorrhagic fever, is associated with sequential infections with heterologous serotypes. While there currently is no precisely defined correlate of protection, durable tetravalent immunity is the desired outcome of dengue vaccination. A Phase 1 clinical trial was conducted at the Walter Reed ArmyInstitute of Research (WRAIR), WRAIR #2136, using live attenuated virus (LAV)and purified inactivated virus (PIV) vaccine candidates containing all fourserotypes. The two products were tested in a prime-boost regimen (PIV followed by LAV and vice versa) in different schedules to determine if dosing schedule or order of administration affected neutralizing antibody levels and/or cell mediated responses. Utilizing a three color Fluorospot assay to measure DENV-specific IgG, IgA, and IgM secreting cells, we tested 6-months post second dose memory B cell cultures to determine if the response was tetravalent and if a change in vaccination strategy affected the valency. We also investigated how memory B cell responses correlated to neutralizing antibody data. Results show that a majority of subjects have a robust multivalent DENV-specific IgG memory B cell response at 6 months post-vaccination. A better understanding of memory B cell responses and how they relate to neutralizing antibody will help find a suitable DENV vaccine that provides durable tetravalent immunity." @default.
- W4313385192 created "2023-01-06" @default.
- W4313385192 creator A5003994833 @default.
- W4313385192 creator A5026217717 @default.
- W4313385192 creator A5044428939 @default.
- W4313385192 creator A5077150218 @default.
- W4313385192 creator A5077522136 @default.
- W4313385192 creator A5086456758 @default.
- W4313385192 creator A5087325576 @default.
- W4313385192 date "2017-05-01" @default.
- W4313385192 modified "2023-09-27" @default.
- W4313385192 title "A Prime-Boost Dengue Vaccination Strategy Induces Durable Multivalent Memory B Cell Responses" @default.
- W4313385192 doi "https://doi.org/10.4049/jimmunol.198.supp.122.16" @default.
- W4313385192 hasPublicationYear "2017" @default.
- W4313385192 type Work @default.
- W4313385192 citedByCount "0" @default.
- W4313385192 crossrefType "journal-article" @default.
- W4313385192 hasAuthorship W4313385192A5003994833 @default.
- W4313385192 hasAuthorship W4313385192A5026217717 @default.
- W4313385192 hasAuthorship W4313385192A5044428939 @default.
- W4313385192 hasAuthorship W4313385192A5077150218 @default.
- W4313385192 hasAuthorship W4313385192A5077522136 @default.
- W4313385192 hasAuthorship W4313385192A5086456758 @default.
- W4313385192 hasAuthorship W4313385192A5087325576 @default.
- W4313385192 hasConcept C10389963 @default.
- W4313385192 hasConcept C159047783 @default.
- W4313385192 hasConcept C159654299 @default.
- W4313385192 hasConcept C196594336 @default.
- W4313385192 hasConcept C203014093 @default.
- W4313385192 hasConcept C22070199 @default.
- W4313385192 hasConcept C2522874641 @default.
- W4313385192 hasConcept C2778453870 @default.
- W4313385192 hasConcept C2779261636 @default.
- W4313385192 hasConcept C2779308166 @default.
- W4313385192 hasConcept C2779341262 @default.
- W4313385192 hasConcept C2779359726 @default.
- W4313385192 hasConcept C2779635636 @default.
- W4313385192 hasConcept C2780568436 @default.
- W4313385192 hasConcept C2780791431 @default.
- W4313385192 hasConcept C2780801004 @default.
- W4313385192 hasConcept C533803919 @default.
- W4313385192 hasConcept C71924100 @default.
- W4313385192 hasConcept C86803240 @default.
- W4313385192 hasConcept C8891405 @default.
- W4313385192 hasConceptScore W4313385192C10389963 @default.
- W4313385192 hasConceptScore W4313385192C159047783 @default.
- W4313385192 hasConceptScore W4313385192C159654299 @default.
- W4313385192 hasConceptScore W4313385192C196594336 @default.
- W4313385192 hasConceptScore W4313385192C203014093 @default.
- W4313385192 hasConceptScore W4313385192C22070199 @default.
- W4313385192 hasConceptScore W4313385192C2522874641 @default.
- W4313385192 hasConceptScore W4313385192C2778453870 @default.
- W4313385192 hasConceptScore W4313385192C2779261636 @default.
- W4313385192 hasConceptScore W4313385192C2779308166 @default.
- W4313385192 hasConceptScore W4313385192C2779341262 @default.
- W4313385192 hasConceptScore W4313385192C2779359726 @default.
- W4313385192 hasConceptScore W4313385192C2779635636 @default.
- W4313385192 hasConceptScore W4313385192C2780568436 @default.
- W4313385192 hasConceptScore W4313385192C2780791431 @default.
- W4313385192 hasConceptScore W4313385192C2780801004 @default.
- W4313385192 hasConceptScore W4313385192C533803919 @default.
- W4313385192 hasConceptScore W4313385192C71924100 @default.
- W4313385192 hasConceptScore W4313385192C86803240 @default.
- W4313385192 hasConceptScore W4313385192C8891405 @default.
- W4313385192 hasIssue "1_Supplement" @default.
- W4313385192 hasLocation W43133851921 @default.
- W4313385192 hasOpenAccess W4313385192 @default.
- W4313385192 hasPrimaryLocation W43133851921 @default.
- W4313385192 hasRelatedWork W2005243362 @default.
- W4313385192 hasRelatedWork W2056019569 @default.
- W4313385192 hasRelatedWork W2081356962 @default.
- W4313385192 hasRelatedWork W2100364502 @default.
- W4313385192 hasRelatedWork W2124479668 @default.
- W4313385192 hasRelatedWork W2796075691 @default.
- W4313385192 hasRelatedWork W2809057058 @default.
- W4313385192 hasRelatedWork W3088007661 @default.
- W4313385192 hasRelatedWork W3102957462 @default.
- W4313385192 hasRelatedWork W3134718598 @default.
- W4313385192 hasVolume "198" @default.
- W4313385192 isParatext "false" @default.
- W4313385192 isRetracted "false" @default.
- W4313385192 workType "article" @default.