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- W4313385251 abstract "Abstract Naïve T cells interact with dendritic cells (DCs) in lymph nodes to become activated and effect a specific immune response. The chemokine CCL21 and lysophosphatidic acid (LPA) have both been demonstrated to be important for T cell movement within the T cell zone of the lymph node. However, the residual motility in the absence of both CCL21 signaling via CCR7 and LPA suggest that additional molecules can play a role in driving T cell movement within lymph nodes. Using two photon microscopy, we show interleukin-7 (IL-7) promotes T cell motility in vitro and in vivo, in addition to its known function as a survival factor. Blocking IL-7 signaling in the lymph node elicited a reduction in T cell speed. IL-7 treatment of primary T cells in vitro resulted in increased migration across a permeable barrier and small GTPase RhoA activation. We further demonstrate that IL-7 combines with CCL21 and LPA to promote naïve T cell motility. Our results indicate that IL-7 is a novel regulator of T cell motion in lymph nodes, in addition to its effect on T cell survival." @default.
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- W4313385251 date "2017-05-01" @default.
- W4313385251 modified "2023-09-27" @default.
- W4313385251 title "Interleukin 7 promotes motility of naive T cells in the lymph node" @default.
- W4313385251 doi "https://doi.org/10.4049/jimmunol.198.supp.63.9" @default.
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