Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313385269> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313385269 endingPage "131.22" @default.
- W4313385269 startingPage "131.22" @default.
- W4313385269 abstract "Abstract Systemic candidiasis (SC) is a leading cause of nosocomial bloodstream infections, with mortality of >40% despite therapy. In a mouse model of SC, the most highly infected organ is the kidney, and myeloid cells, including dendritic cells (DCs), are integral for host defense. We hypothesized that Ccr7, which mediates DC trafficking and survival, is critical for host defense during SC. Ccr7 and its ligands, Ccl19 and Ccl21, were highly up-regulated in the Candida-infected kidney. All Ccr7−/− mice rapidly succumbed during SC, whereas WT mice had 80% survival at day 14. Infected Ccr7−/− mice had significantly greater kidney fungal burden, with greater tissue damage, and more severe renal failure. Infection in Ccl19−/− mice and in plt/plt mice (that lack Ccl19 and the CCL21a isoform of Ccl21) did not phenocopy the susceptibility of Ccr7−/− mice, indicating that the CCL21b-Ccr7 axis is critical for protection. Surprisingly, bone marrow chimeras revealed that the protective effects of Ccr7 are solely mediated by non-hematopoietic cells. Studies using FACS, IHC, and mRNA from sorted renal cells showed that Ccr7 is expressed by renal tubular cells (RTCs), not other renal stromal cells. Our preliminary data show the Ccr7 is a survival factor for RTCs; indeed, Ccr7 deficiency resulted in significantly greater tubulitis and tubular necrosis during SC. The renal protective effects of Ccr7 were also evident during bacterial sepsis, indicating that Ccr7 is broadly protective against infection-induced acute kidney injury. In summary, our data are the first to implicate Ccr7 in innate control of any pathogen and to uncover the contribution of Ccr7 on non-hematopoietic cells in protection against acute kidney injury and systemic fungal infection." @default.
- W4313385269 created "2023-01-06" @default.
- W4313385269 creator A5018766597 @default.
- W4313385269 creator A5021490603 @default.
- W4313385269 creator A5022799608 @default.
- W4313385269 creator A5026399142 @default.
- W4313385269 creator A5036817167 @default.
- W4313385269 creator A5066801560 @default.
- W4313385269 creator A5088519518 @default.
- W4313385269 creator A5088538951 @default.
- W4313385269 date "2017-05-01" @default.
- W4313385269 modified "2023-09-25" @default.
- W4313385269 title "Ccr7-dependent amelioration of renal tubular injury protects against infection-induced acute kidney injury" @default.
- W4313385269 doi "https://doi.org/10.4049/jimmunol.198.supp.131.22" @default.
- W4313385269 hasPublicationYear "2017" @default.
- W4313385269 type Work @default.
- W4313385269 citedByCount "0" @default.
- W4313385269 crossrefType "journal-article" @default.
- W4313385269 hasAuthorship W4313385269A5018766597 @default.
- W4313385269 hasAuthorship W4313385269A5021490603 @default.
- W4313385269 hasAuthorship W4313385269A5022799608 @default.
- W4313385269 hasAuthorship W4313385269A5026399142 @default.
- W4313385269 hasAuthorship W4313385269A5036817167 @default.
- W4313385269 hasAuthorship W4313385269A5066801560 @default.
- W4313385269 hasAuthorship W4313385269A5088519518 @default.
- W4313385269 hasAuthorship W4313385269A5088538951 @default.
- W4313385269 hasConcept C126322002 @default.
- W4313385269 hasConcept C127801297 @default.
- W4313385269 hasConcept C12823836 @default.
- W4313385269 hasConcept C13373296 @default.
- W4313385269 hasConcept C203014093 @default.
- W4313385269 hasConcept C2776914184 @default.
- W4313385269 hasConcept C2778049957 @default.
- W4313385269 hasConcept C2778384902 @default.
- W4313385269 hasConcept C2780091579 @default.
- W4313385269 hasConcept C2780472472 @default.
- W4313385269 hasConcept C71924100 @default.
- W4313385269 hasConcept C86803240 @default.
- W4313385269 hasConceptScore W4313385269C126322002 @default.
- W4313385269 hasConceptScore W4313385269C127801297 @default.
- W4313385269 hasConceptScore W4313385269C12823836 @default.
- W4313385269 hasConceptScore W4313385269C13373296 @default.
- W4313385269 hasConceptScore W4313385269C203014093 @default.
- W4313385269 hasConceptScore W4313385269C2776914184 @default.
- W4313385269 hasConceptScore W4313385269C2778049957 @default.
- W4313385269 hasConceptScore W4313385269C2778384902 @default.
- W4313385269 hasConceptScore W4313385269C2780091579 @default.
- W4313385269 hasConceptScore W4313385269C2780472472 @default.
- W4313385269 hasConceptScore W4313385269C71924100 @default.
- W4313385269 hasConceptScore W4313385269C86803240 @default.
- W4313385269 hasIssue "1_Supplement" @default.
- W4313385269 hasLocation W43133852691 @default.
- W4313385269 hasOpenAccess W4313385269 @default.
- W4313385269 hasPrimaryLocation W43133852691 @default.
- W4313385269 hasRelatedWork W2112959575 @default.
- W4313385269 hasRelatedWork W2136650715 @default.
- W4313385269 hasRelatedWork W2350237293 @default.
- W4313385269 hasRelatedWork W2984017515 @default.
- W4313385269 hasRelatedWork W3003790982 @default.
- W4313385269 hasRelatedWork W3098122996 @default.
- W4313385269 hasRelatedWork W4229041784 @default.
- W4313385269 hasRelatedWork W4283688683 @default.
- W4313385269 hasRelatedWork W4321442582 @default.
- W4313385269 hasRelatedWork W4324130264 @default.
- W4313385269 hasVolume "198" @default.
- W4313385269 isParatext "false" @default.
- W4313385269 isRetracted "false" @default.
- W4313385269 workType "article" @default.