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- W4313385423 abstract "Abstract Previous work has shown that the induction of CD8 T cell anergy to a prostate-specific self-antigen can be reversed following ligation of the TNFR family member OX40 (CD134) with an agonist anti-OX40 mAb plus vaccination. The provision of the Toll-like receptor 4 (TLR4) ligand bacterial lipopolysaccharide (LPS) further enhanced T cell responses following combined anti-OX40/vaccine immunotherapy. Although this approach facilitated increased CD8 T cell infiltration into the prostate, these cells were unable to elicit significant destruction of the prostate tissue. In the current study, we examined the extent to which co-administration of select TLR ligands would affect the ability of anti-OX40/vaccine therapy to revive prostate-specific CD8 T cells rendered anergic in vivo. These data revealed a differential capability of TLR agonists in conjunction with anti-OX40/vaccine immunotherapy to generate robust effector CD8 T cells capable of trafficking into normal prostate epithelia and inducing tissue-specific damage. These data provide the framework for translational studies to evaluate the efficacy of administering OX40 agonists with tumor-specific vaccination and TLR ligand adjuvants to maximize T cell-mediated therapeutic responses." @default.
- W4313385423 created "2023-01-06" @default.
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- W4313385423 date "2016-05-01" @default.
- W4313385423 modified "2023-09-27" @default.
- W4313385423 title "Toll-like receptor ligands in conjunction with agonist anti-OX40 mAb immunotherapy possess differential capacity to revive anergic self-reactive CD8 T cells" @default.
- W4313385423 doi "https://doi.org/10.4049/jimmunol.196.supp.215.4" @default.
- W4313385423 hasPublicationYear "2016" @default.
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